SkinCeuticals TNXA-SHOT Discoloration Defense
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SkinCeuticals' new brightening shot in a serum. TNXA-SHOT replaces Discoloration Defense with a patent-pending 5% tranexamic acid complex, 3% Endophytol and 1% alpha-amino acid to help visibly reduce persistent dark spots that can resist lasers alone. Tested on all skin tones.
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Description
A brightening shot in a serum: 5% tranexamic acid for persistent dark spots that can resist lasers alone
Size: 30 mL / 1 fl. oz.
Suitable for: All skin types and tones, including dry, normal, oily, combination and sensitive skin; tested on all skin tones.
Targeted concerns: Persistent dark spots, stubborn brown patches, post-blemish marks, sun-triggered and hormone-triggered discolouration, uneven skin tone, dullness
SkinCeuticals TNXA-SHOT Discoloration Defense is the new daily brightening serum that replaces the original Discoloration Defense in Canada. Its patent-pending complex pairs 5% tranexamic acid (40% more than the previous formula) with 3% Endophytol and 1% alpha-amino acid to address the three triggers that keep dark spots coming back: sun and pollution, hormonal signals and the skin's own stress response. A second multi-phase complex of 4% niacinamide, 0.15% SymWhite 377, 0.15% LHA and 0.2% carnosine works on pigment production, pigment transfer, surface renewal and antioxidant protection, so the formula helps visibly reduce persistent discolouration from several directions at once. The milky-white serum is lightweight with a fresh finish, layers under moisturizer and SPF, and is physician-tested to complement in-clinic laser treatments.
What is new versus Discoloration Defense
- 5% tranexamic acid (up from 3%), SkinCeuticals' highest concentration to date
- 3% Endophytol, the dandelion-root patent also found in the 2026 C E Ferulic, to counter pollution-triggered pigment
- 1% alpha-amino acid to intercept the hormonal pigment signal
- 4% niacinamide, 0.15% SymWhite 377, 0.15% LHA and 0.2% carnosine replace kojic acid and HEPES
- New milky-white texture, lightweight and fresh instead of yellow and sticky
SkinCeuticals TNXA-SHOT FAQs
Is TNXA-SHOT the same as Discoloration Defense?
No. TNXA-SHOT is the 2026 successor. Discoloration Defense has been discontinued in Canada and TNXA-SHOT takes its place with a higher 5% tranexamic acid concentration, two new actives and a new texture.
How do I use TNXA-SHOT?
Apply 4 to 5 drops to clean, dry face and neck morning and night. In the morning follow with your SkinCeuticals vitamin C, moisturizer and SPF; at night apply before moisturizer.
Can I use it after a laser treatment?
TNXA-SHOT is physician-tested to complement laser treatments for discolouration. Follow your provider's timing on when to resume actives after any procedure.
Is it authentic and shipped in Canada?
Yes. WeDoSkin.ca is an authorized Canadian retailer of SkinCeuticals, with authentic, fresh stock shipped Canada-wide.
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Let customers speak for us
This is a great product. Goes on smoothly and sets the face up for the day ahead!
I love this product , very hydrating , great for fine lines
Perfect
This product is amazing! No peeling, no dry skin. The best I’ve ever used!
Best ultralight moisturizer I've used - WeDo said I would get a free Product with this purchase. Didnt show in the package - sent customer service a followup email - no answer.
Not thrilled with their customer service even if pricing is good
Very hydrating!!!!
LOVE this product. It makes my shin hydrated and even affects the redness, by clearing it up to a more natural and healthy look.
I have been using Alumier for several years and am happy with the product.
My first time using this new product. Have to say I love it, cleans my face without stripping and drying it out.
Always the best products. Love the bright and clear solution. Leaving my skin glowing.
I have become quickly obsessed with this duo. Great for skin!
Really like the way this product glides onto the skin. Great in combination with Collin Bio-Peptides.
Leaves a lovely glow and does not clog pores. I have repurchased.
This product has been in my rotation for a few years now. I usually use it 2-3 times a week. I find it really helps with small blemishes. I use it on freshly washed skin at night only and then apply a moisturizer over after giving it a few minutes to sink in. A little goes a long way with retinol - apply very sparingly!
A little goes a long way and it's very gentle! My laser genesis technician recommended it for my acne prone skin along with hydra-cool and active serum. Between the laser genesis (6 sessions spread out 2 weeks apart followed by monthly maintenance sessions) and these products I have managed to finally end a 12 year battle with severe acne!
Love this serum! It is very hydrating and absorbs quickly! My laser genesis technician recommended it (in replacement of moisturizer) for my acne prone skin along with active serum and the cleansing complex. Between the laser genesis (6 sessions spread out 2 weeks apart followed by monthly maintenance sessions) and these products I have managed to finally end a 12 year battle with severe acne!
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SkinCeuticals TNXA-SHOT: The 5% Tranexamic Acid Shot for Dark Spots That Will Not Quit
SkinCeuticals TNXA-SHOT Discoloration Defense is the new daily brightening serum built for persistent dark spots that can resist lasers alone: a patent-pending complex of 5% tranexamic acid, 3% Endophytol and 1% alpha-amino acid that goes after the sun, hormone and stress signals that keep pigment coming back.
A second multi-phase complex (4% niacinamide, 0.15% SymWhite 377, 0.15% LHA, 0.2% carnosine) works on pigment production, transfer and surface renewal. Milky-white, lightweight, tested on all skin tones, and the successor to Discoloration Defense in Canada. WeDoSkin.ca is an Authorized SkinCeuticals Retailer in Canada, with authentic, fresh stock.
5% Tranexamic Acid
The highest concentration SkinCeuticals has made.
3 Triggers, 1 Serum
Environmental, hormonal and stress pigment signals.
Multi-Phase Brightening
Production, transfer, surface and antioxidant steps.
Laser Complement
Physician-tested alongside in-clinic treatments.
Key Ingredients & How They Work
The actives that drive TNXA-SHOT — and what each one does for your skin.
Interrupts the pigment alarm
Calms the signal that tells melanocytes to overproduce after sun, heat or hormonal shifts.
Pollution and hormones
Dandelion-root patent for pollution-triggered pigment; alpha-amino acid intercepts the alpha-MSH hormone signal.
Production and transfer
SymWhite deactivates tyrosinase; niacinamide limits melanin transfer to surface cells.
Renew and protect
LHA sheds pigment-loaded surface cells; carnosine neutralizes free radicals and glycation stress.
These descriptions reflect how each ingredient works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.
Benefits of TNXA-SHOT
What TNXA-SHOT Pairs Well With
Build a complete routine — these pairings are most often recommended alongside TNXA-SHOT. Tap any product to shop.
SkinCeuticals Phloretin CF® à l’acide férulique$230.00Shop now →
SkinCeuticals C E Ferulic — Nouvelle formule 2026$230.00Shop now →
SkinCeuticals Physical Fusion UV Defense FPS 50$68.00Shop now →
SkinCeuticals Advanced RGN-6$255.00Shop now →How to Use
- Apply 4 to 5 drops to clean face and neck morning and night.
- AM: after vitamin C, before moisturizer and SPF. PM: before moisturizer.
- Daily SPF is what keeps the results; never skip it.
Who It's For
- Persistent dark spots and brown patches
- Post-blemish marks and uneven tone
- Between or after laser sessions
- All skin types and tones
Sensitivity note: A lightweight, fragrance-conscious brightening serum tested on all skin tones; patch test if highly reactive and pair with daily SPF.
How TNXA-SHOT Compares
Where TNXA-SHOT sits relative to other options. The right fit depends on your skin and goals.
| Feature | TNXA-SHOT | Phloretin CF | Phyto A+ Brightening |
|---|---|---|---|
| Hero | 5% tranexamic acid complex | Vitamin C + phloretin | Phyto actives + brighteners |
| Focus | Persistent dark spots | Tone + early aging | Brightening moisturizer |
| When | AM and PM | AM | AM or PM |
| Texture | Milky, lightweight | Water-light serum | Gel-cream |
| Tones | Tested on all | All | All |
TNXA-SHOT: Frequently Asked Questions
What is SkinCeuticals TNXA-SHOT Discoloration Defense?
TNXA-SHOT is SkinCeuticals' new daily brightening serum for persistent dark spots. Its patent-pending complex combines 5% tranexamic acid, 3% Endophytol and 1% alpha-amino acid with 4% niacinamide, 0.15% SymWhite 377, 0.15% LHA and 0.2% carnosine. It launches in Canada in November 2026 at $170 CAD for 30 mL.
Is TNXA-SHOT replacing Discoloration Defense?
Yes. SkinCeuticals has discontinued Discoloration Defense in Canada. TNXA-SHOT is the upgrade: 5% tranexamic acid instead of 3%, two new actives for pollution and hormonal pigment triggers, and a milky-white texture that is lighter and less sticky.
What does tranexamic acid do for dark spots?
Tranexamic acid helps quiet the signal that tells pigment cells to overproduce melanin after sun exposure, heat or hormonal changes. That makes it one of the most useful actives for stubborn, recurring discolouration, and TNXA-SHOT carries it at 5%, SkinCeuticals' highest concentration.
Can TNXA-SHOT be used with laser treatments?
SkinCeuticals positions TNXA-SHOT as the at-home complement to laser treatments for discolouration and reports it is physician-tested alongside them. Persistent pigment can resist laser alone and can return after treatment, so a daily topical plus strict SPF is the usual recommendation. Always follow your provider's timing on resuming actives.
How do I layer TNXA-SHOT with vitamin C and retinol?
Morning: C E Ferulic or Phloretin CF first, then TNXA-SHOT, then moisturizer and SPF. Evening: TNXA-SHOT on clean skin, let it absorb, then your retinol or moisturizer. It is formulated to be layerable.
Is TNXA-SHOT suitable for sensitive skin and deeper skin tones?
It is tested on all skin tones and formulated for all skin types including sensitive. If your skin is highly reactive, patch test first and introduce it once daily before moving to morning and night.
How long until I see results?
SkinCeuticals' clinical study on the final formula is still in progress at launch, so we are not quoting a timeline or percentage. As with any brightening serum, expect gradual change over weeks of consistent twice-daily use with sunscreen, and we will update this page when the brand publishes its results.
Where can I buy SkinCeuticals TNXA-SHOT in Canada?
WeDoSkin.ca is an authorized Canadian SkinCeuticals retailer. TNXA-SHOT Discoloration Defense is $170 CAD, ships free across Canada, and arrives as fresh, authentic stock from Canadian distribution.
This page is reviewed under the medical oversight of the WeDoSkin Clinic in Calgary. As a Preferred Authorized Retailer, our clinical team works directly with these brands and handles these formulas every day. Information here is educational and not a substitute for personalized medical advice.
Explore Related Concerns & Ingredients
The concern and ingredient hubs TNXA-SHOT most often appears in at WeDoSkin.
Pourquoi les Canadiens choisissent WeDoSkin
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