NeoGenesis Skin Restore Serum
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Skin Restore Serum is the NeoGenesis answer to vitamin A. Instead of traditional retinol, it uses hydroxypinacolone retinoate (HPR), a next-generation retinoid that binds directly to retinoid receptors in the skin.
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Description
Size: 5 mL / 15 mL / 30 mL
Skin Types: All skin types, including sensitive
Skin Concerns: Fine lines and wrinkles, uneven tone and dark spots, rough texture and dullness, breakouts and congestion, early visible signs of aging, skin that reacts to traditional retinol, all skin types
Skin Restore Serum is the NeoGenesis vitamin A serum, built around hydroxypinacolone retinoate (HPR), a next-generation retinoid that binds directly to the skin's retinoid receptors. NeoGenesis pairs it with beta-carotene, carrot root and seed extracts, N-acetyl-D-glucosamine, and nourishing sunflower seed oil and squalane, so the formula supports aging and blemish-prone skin without irritation while leaving skin smoother, firmer and brighter.
It supports collagen and the skin's natural renewal to soften the look of fine lines and wrinkles, encourages cell turnover to improve the appearance of uneven tone, dark spots and dullness, and helps maintain clear-looking pores. Dermatologist recommended and made for all skin types, it is applied after cleansing and your S2RM serum: one pump to the face, allowed to absorb, then moisturizer as needed. NeoGenesis pairs it with Recovery to amplify results.
Watch: Skin Restore Serum explained
NeoGenesis made this short product video for Skin Restore Serum, so you can see the texture, the application and where it fits in a routine before you buy.
Real results with Skin Restore Serum
NeoGenesis publishes before and after photos from its professional partners. These cases used Skin Restore Serum as part of a NeoGenesis routine, and each caption lists every product involved.
Photos courtesy of NeoGenesis professional partners. Individual results vary.
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Very soothing after microneedling. Apply liberally to calm any itching!
Favorite cleanser. I have purchased it 4 times already and I tried to switch to another brand and I always end up going back to this one. I have very sensitive skin and my pores get clogged very easily. This cream cleanser is soothing and does an excellent job cleansing my face. I use it in the morning and as a second cleanse at time. A little bit goes a long way and although it doesn’t have a scent, the experience of washing your face with it is so pleasant and satisfying. I am done trying new cleansers.
Favorite SPF. I have tried so many different SPF and brands. They would be too greasy and/or sting my eyes after a few hours and/or irritate my sensitive skin and/or clog my pores. I finally found the one! Is it lightweight, non greasy, protects very well, sweat resistant, doesn’t irritate my skin or clog my pores. On top of that a little bit goes a long way. This is my third bottle and my quest for the best SPF for my skin is finally over.
Très bien marché bien et j’achèterais surement un autre
I love this product, the Vivier Sheer SPF30 Mineral tinted sunscreen. I love the creamy easy to apply non scented cream that just glides and covers light skin imperfections. I will definitely re-order again.
I love this product!Used 0.3 before and increased to 0.5 with sude effects.
This cleanser polish is a povely
I’ve been using this product for a year and it’s the only thing that’s worked for my face to help it heal and clear up my skin. I’ve been trying a lot of other products and this one works! Highly recommend!
Very nice, i love this product
Beautiful packaging and looks very high end. I've been using for 2 weeks now and its easy to use. I like how it automatically turns off in 10 mins.
The perfect complement to my pigment control routine - with hydroquinone part of the year, and office laser treatments. This product is excellent, and works well layering. No pilling!
Love this formula! 10/10 great for mature skin
Love this brand already but this was my first time trying these products. A great deal getting them in this kit! My fave is the exfoliating polish, it is amazing! Feels so invigorating, and after my skin feels so soft and fresh.
Excellent product.face mask protection. I visited to Cusco where there is a very high altitude so that the sun radiation is extremely intense. The mask protection worked well!!
I’ve been using this for almost a decade! Love it!
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Skin Restore Serum: next-generation vitamin A, minus the irritation
Skin Restore Serum is the NeoGenesis answer to vitamin A. Instead of traditional retinol, it uses hydroxypinacolone retinoate (HPR), a next-generation retinoid that binds directly to retinoid receptors in the skin. NeoGenesis positions HPR as a retinoate that works without the conversion steps retinol needs, with a gentler feel on the skin. Around it sit beta-carotene, carrot root and seed extracts, N-acetyl-D-glucosamine, tocopherol and nourishing sunflower seed oil and squalane, so renewal comes with comfort rather than flaking.
It is built for skin that wants the visible benefits of vitamin A: softer fine lines and wrinkles, a more even tone, less visible dark spots, smoother texture and more radiance, plus support for blemish-prone skin by helping keep pores clear. NeoGenesis describes it as suiting aging and blemish-prone skin alike, without irritation. Apply one pump after cleansing and your S2RM serum, let it absorb, then moisturize as needed. Dermatologist recommended and made for all skin types.
HPR, a next-generation retinoid
Hydroxypinacolone retinoate binds directly to retinoid receptors and is readily used by the skin, with less irritation than traditional forms.
Carotenoids and antioxidants
Beta-carotene, carrot root and seed extracts and tocopherol help protect against free radicals and brighten the look of skin.
Lines, tone, texture
Supports collagen and natural renewal for softer lines, a more even tone and smoother, more radiant skin.
Kind to blemish-prone skin
Helps maintain clear-looking pores, with lightweight sunflower seed oil and squalane that nourish without heaviness.
Key Ingredients & How They Work
The actives that drive HPR vitamin A with carotenoids: smoother, brighter, clearer-looking skin without the retinol irritation. — and what each one does for your skin.
Why HPR
HPR binds directly to the skin's retinoid receptors, which is what sets it apart from traditional retinol. NeoGenesis positions it as a gentler alternative to traditional retinol.
Renewal and collagen
Vitamin A supports collagen and the skin's natural cell turnover, which is how it softens the look of fine lines and wrinkles and improves the appearance of uneven tone, dark spots and rough texture.
N-acetyl-D-glucosamine
Included alongside HPR and antioxidants to address multiple visible signs of aging, including uneven tone, dullness and loss of radiance, while keeping skin comfortable.
Barrier support
Sunflower seed oil, squalane, glycerin and propanediol condition and hydrate, supporting the look of a well-functioning moisture barrier, suppleness and elasticity.
These descriptions reflect how each ingredient works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.
Benefits of HPR vitamin A with carotenoids: smoother, brighter, clearer-looking skin without the retinol irritation.
What HPR vitamin A with carotenoids: smoother, brighter, clearer-looking skin without the retinol irritation. Pairs Well With
Build a complete routine — these pairings are most often recommended alongside HPR vitamin A with carotenoids: smoother, brighter, clearer-looking skin without the retinol irritation.. Tap any product to shop.
NeoGenesis Recovery$100.00Shop now →
NeoGenesis Booster$80.00Shop now →
NeoGenesis Intensive Moisturizer$30.00Shop now →
NeoGenesis Mandelic Acid 8%$20.00Shop now →How to Use
- After cleansing and applying your S2RM serum, apply one pump to the face.
- Allow it to absorb fully, then follow with moisturizer as needed.
- Wear sunscreen daily, as you would with any vitamin A product. NeoGenesis pairs Skin Restore Serum with Recovery to amplify results.
Who It's For
- Fine lines, wrinkles and early visible signs of aging
- Uneven tone, dark spots, rough texture and dullness
- Blemish-prone or congested skin that also wants anti-aging support
- Anyone who wants vitamin A results but has not tolerated traditional retinol
Sensitivity note: NeoGenesis formulates Skin Restore Serum to support aging and blemish-prone skin without irritation, using HPR rather than traditional retinol. It is dermatologist recommended and made for all skin types; if your skin is very reactive, start a few evenings a week and build up, and always follow with moisturizer as needed.
How HPR vitamin A with carotenoids: smoother, brighter, clearer-looking skin without the retinol irritation. Compares
Where HPR vitamin A with carotenoids: smoother, brighter, clearer-looking skin without the retinol irritation. sits relative to other options. The right fit depends on your skin and goals.
| Feature | NeoGenesis Skin Restore Serum | Other Growth Factor Serums | Drugstore Serums |
|---|---|---|---|
| Form of vitamin A | Hydroxypinacolone retinoate (HPR), binds directly to retinoid receptors | Retinol, requires conversion in the skin | Retinol or retinyl palmitate at low strength |
| Irritation | Formulated to work without irritation, per the studies NeoGenesis cites | Dryness, flaking and redness are common while adjusting | Milder, but often less visible benefit |
| Supporting actives | Carotenoids, N-acetyl-D-glucosamine, tocopherol, squalane and sunflower seed oil | Varies, often minimal | Basic emollients |
| Routine fit | After S2RM serum, one pump, then moisturizer as needed | Evenings only, with a slow ramp | Evenings only |
HPR vitamin A with carotenoids: smoother, brighter, clearer-looking skin without the retinol irritation.: Frequently Asked Questions
What is NeoGenesis Skin Restore Serum?
It is the NeoGenesis vitamin A serum. Instead of traditional retinol it uses hydroxypinacolone retinoate (HPR), combined with carotenoids, N-acetyl-D-glucosamine and antioxidants, to provide a comprehensive approach to skin renewal: softer fine lines and wrinkles, a more even tone, smoother texture, more radiance and clearer-looking pores, with both immediate and long-term benefits.
How do I use Skin Restore Serum?
After cleansing and applying your S2RM serum (Recovery, Booster or Skin Serum), apply one pump to the face and allow it to absorb fully. Follow with moisturizer as needed and wear sunscreen during the day. It comes in 5 mL, 15 mL and 30 mL.
Who should use Skin Restore Serum?
NeoGenesis recommends it for anyone looking to improve the appearance of fine lines, wrinkles, uneven tone, rough texture, dullness or early visible signs of aging, and for blemish-prone skin that wants help keeping pores clear. It is especially well suited to people who want the benefits of vitamin A in a gentler formula than traditional retinol products.
What is hydroxypinacolone retinoate (HPR)?
HPR is a next-generation vitamin A ingredient that binds directly to retinoid receptors in the skin, so it does not rely on the conversion steps that retinol needs. NeoGenesis positions HPR as a retinoate that works without the conversion steps retinol needs, with a gentler feel on the skin.
How is this different from a regular retinol serum?
Regular retinol has to be converted in the skin before it works, and the adjustment period often brings dryness, flaking and redness. Skin Restore Serum uses HPR, which the skin can use directly, and surrounds it with carotenoids, tocopherol, squalane and sunflower seed oil. NeoGenesis positions it as a comfortable vitamin A option for both aging and blemish-prone skin.
Can I use it with Recovery, vitamin C or exfoliating acids?
Recovery is the pairing NeoGenesis recommends: apply the S2RM serum first, then Skin Restore Serum. The brand also lists Mandelic Acid 8% among its pairings. If you combine vitamin A with an exfoliating acid, consider alternating evenings and keep sunscreen in the routine every day, since acids can increase sun sensitivity.
Are there before and after photos for Skin Restore Serum?
Yes. NeoGenesis publishes before and after case photos from its professional partners, and a selection that used Skin Restore Serum is shown above with every product in the routine listed in the caption. Individual results vary.
Is there a video on how to use Skin Restore Serum?
Yes. The NeoGenesis product video above walks through Skin Restore Serum, what is in it and how to apply it, and the science video explains the stem cell released molecules behind the line.
This page is reviewed under the medical oversight of the WeDoSkin Clinic in Calgary. As a Preferred Authorized Retailer, our clinical team works directly with these brands and handles these formulas every day. Information here is educational and not a substitute for personalized medical advice.
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