Preferred Authorized Canadian Retailer

iS Clinical

iS Clinical is clinical-grade skincare rooted in pharmaceutical botany — potent botanicals and advanced actives validated through independent clinical trials. The iconic Active Serum and Youth line deliver rapid, visible results for aging, acne, and dull, dehydrated skin. WeDoSkin.ca is a Preferred Authorized Canadian Retailer of iS Clinical, with authentic, fresh stock.

iS Clinical Routine
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iS Clinical

iS Clinical

Pharmaceutical-grade botanicals that deliver rapid, visible improvements. The science of 'Active' skincare for anti-aging and acne.

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  • iS Clinical Active Serum iS Clinical Active Serum

    iS Clinical Active Serum

    $204.00
    $204.00
    $204.00
    Earn 5% Cashback
  • iS Clinical Cream Cleanser iS Clinical Cream Cleanser

    iS Clinical Cream Cleanser

    $58.00
    $58.00
    $58.00
    Earn 5% Cashback
  • iS Clinical Reparative Moisture Emulsion iS Clinical Reparative Moisture Emulsion

    iS Clinical Reparative Moisture Emulsion

    $151.00
    $151.00
    $151.00
    Earn 5% Cashback
  • iS Clinical Active Peel System iS Clinical Active Peel System

    iS Clinical Active Peel System

    $132.00
    $132.00
    $132.00
    Earn 5% Cashback
  • iS Clinical Eclipse SPF50+ (Translucent) iS Clinical Eclipse SPF50+ (Translucent)

    iS Clinical Eclipse SPF50+ (Translucent)

    $72.00
    $72.00
    $72.00
    Earn 5% Cashback
  • iS Clinical Warming Honey Cleanser iS Clinical Warming Honey Cleanser

    iS Clinical Warming Honey Cleanser

    $72.57
    $72.57
    $52.97
    Earn 5% Cashback
  • iS Clinical Cleansing Complex iS Clinical Cleansing Complex

    iS Clinical Cleansing Complex

    $69.00
    $69.00
    $69.00
    Earn 5% Cashback
  • C Eye Serum Advance+ C Eye Serum Advance+

    C Eye Serum Advance+

    $98.00
    $98.00
    $98.00
    Earn 5% Cashback
  • iS Clinical Firming Complex iS Clinical Firming Complex

    iS Clinical Firming Complex

    $199.00
    $199.00
    $199.00
    Earn 5% Cashback
  • iS Clinical Youth Complex iS Clinical Youth Complex

    iS Clinical Youth Complex

    $260.26
    $260.26
    $189.97
    Earn 5% Cashback
  • iS Clinical Moisturizing Complex iS Clinical Moisturizing Complex

    iS Clinical Moisturizing Complex

    $141.00
    $141.00
    $141.00
    Earn 5% Cashback
  • iS Clinical Pro-Health Serum Advanced+ iS Clinical Pro-Health Serum Advanced+

    iS Clinical Pro-Health Serum Advanced+

    $226.00
    $226.00
    $226.00
    Earn 5% Cashback
  • iS Clinical Hydra-Intensive Cooling Masque iS Clinical Hydra-Intensive Cooling Masque

    iS Clinical Hydra-Intensive Cooling Masque

    $137.00
    $137.00
    $137.00
    Earn 5% Cashback
  • iS Clinical Retinol + Emulsion 0.3 iS Clinical Retinol + Emulsion 0.3

    iS Clinical Retinol + Emulsion 0.3

    $149.00
    $149.00
    $149.00
    Earn 5% Cashback
  • iS Clinical Brightening Serum iS Clinical Brightening Serum

    iS Clinical Brightening Serum

    $200.00
    $200.00
    $200.00
    Earn 5% Cashback
  • iS Clinical Hydra-Cool Serum iS Clinical Hydra-Cool Serum

    iS Clinical Hydra-Cool Serum

    $142.00
    $142.00
    $142.00
    Earn 5% Cashback
  • iS Clinical Super Serum Advanced+ iS Clinical Super Serum Advanced+

    iS Clinical Super Serum Advanced+

    $226.00
    $226.00
    $226.00
    Earn 5% Cashback
  • iS Clinical Youth Intensive Crème 50g iS Clinical Youth Intensive Crème 50g

    iS Clinical Youth Intensive Crème 50g

    $338.00
    $338.00
    $338.00
    Earn 5% Cashback
  • iS Clinical Brightening Complex iS Clinical Brightening Complex

    iS Clinical Brightening Complex

    $219.00
    $219.00
    $219.00
    Earn 5% Cashback
  • iS Clinical Youth Eye Complex iS Clinical Youth Eye Complex

    iS Clinical Youth Eye Complex

    $144.50
    $144.50
    $144.50
    Earn 5% Cashback
  • iS Clinical Tri-Active Exfoliant Masque iS Clinical Tri-Active Exfoliant Masque

    iS Clinical Tri-Active Exfoliant Masque

    $137.00
    $137.00
    $137.00
    Earn 5% Cashback
  • iS Clinical NeckPerfect Complex iS Clinical NeckPerfect Complex

    iS Clinical NeckPerfect Complex

    $158.00
    $158.00
    $158.00
    Earn 5% Cashback
  • iS Clinical Poly Vitamin Serum iS Clinical Poly Vitamin Serum

    iS Clinical Poly Vitamin Serum

    $165.00
    $165.00
    $165.00
    Earn 5% Cashback
  • Preferred Authorized Retailer
  • 100,000+ Happy Customers
  • Earn 5% Cashback
  • 100-Day Returns*
  • Free Samples

iS Clinical Canada — Botanical Bionutrient Skincare

iS Clinical is a professional skincare brand known for blending botanical bionutrients with clinically meaningful actives — home of the cult Active Serum and Super Serum Advanced+ that practitioners and clients return to again and again.

Shop the full authentic iS Clinical range at WeDoSkin, a Preferred Authorized Retailer, with fast Canada-wide shipping, free samples, and 5% cashback on every order.

🌿

Botanical Science

Plant-derived bionutrients and antioxidants at clinically meaningful strengths.

🔬

Cult Classics

Home of the iconic Active Serum and Super Serum Advanced+.

✨

Visible Results

Targets clarity, brightness, hydration and ageing in elegant formulas.

✅

Authorized & Authentic

Sourced through authorized Canadian distribution — never grey-market.

The Science Behind iS Clinical

How iS Clinical's key actives work — and why formulation and delivery matter as much as the ingredient itself.

SIGNATURE

Active Serum

iS Clinical's cult Active Serum blends bionutrients and botanicals to smooth, brighten and clear — the brand's most recognised formula.

BOTANICAL

Botanical Bionutrients

Formulas are built around plant-derived antioxidants and actives delivered at clinically meaningful concentrations.

BRIGHTEN

Vitamin C & Brightening

Super Serum Advanced+ and the Brightening Serum use vitamin C and botanicals to even tone and support collagen.

PROTECT

Antioxidants & Eclipse SPF

Antioxidant-rich treatments and Eclipse mineral sunscreens defend against daily environmental stress.

These descriptions reflect how each ingredient category works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.

iS Clinical Bestsellers

The most-loved iS Clinical products at WeDoSkin. Tap any product to shop.

iS Clinical Active SerumiS Clinical Active Serum$204.00Shop now →iS Clinical Super Serum Advanced+iS Clinical Super Serum Advanced+$226.00Shop now →iS Clinical Pro-Health Serum Advanced+iS Clinical Pro-Health Serum Advanced+$226.00Shop now →iS Clinical Cleansing ComplexiS Clinical Cleansing Complex$69.00Shop now →iS Clinical Hydra-Cool SerumiS Clinical Hydra-Cool Serum$142.00Shop now →iS Clinical Brightening SerumiS Clinical Brightening Serum$200.00Shop now →iS Clinical Youth ComplexiS Clinical Youth Complex$260.26Shop now →iS Clinical Eclipse SPF50+ (Translucent)iS Clinical Eclipse SPF50+ (Translucent)$72.00Shop now →

Shop the Full iS Clinical Range

Browse every iS Clinical product by category, with live Canadian pricing.

Cleansers
iS Clinical Cream Cleanser$58.00iS Clinical Warming Honey Cleanser$72.57iS Clinical Cleansing Complex$69.00
Eyes, Neck & Lips
iS Clinical Youth Eye Complex$144.50iS Clinical NeckPerfect Complex$158.00
Masks & Peels
iS Clinical Active Peel System$132.00
Moisturizers
iS Clinical Reparative Moisture Emulsion$151.00iS Clinical Firming Complex$199.00iS Clinical Youth Complex$260.26iS Clinical Moisturizing Complex$141.00iS Clinical Youth Intensive Crème 50g$338.00
Non-Tinted Mineral Sunscreens
iS Clinical Eclipse SPF50+ (Translucent)$72.00
Retinols
iS Clinical Retinol + Emulsion 0.3$149.00iS Clinical Brightening Complex$219.00
Serums, Oils & Concentrates
iS Clinical Active Serum$204.00C Eye Serum Advance+$98.00iS Clinical Pro-Health Serum Advanced+$226.00iS Clinical Brightening Serum$200.00iS Clinical Hydra-Cool Serum$142.00iS Clinical Super Serum Advanced+$226.00iS Clinical Poly Vitamin Serum$165.00

How to Choose What's Right for You

New to iS Clinical? Start with your primary concern — here's where most people begin.

Fine Lines & Ageing

Super Serum Advanced+Youth ComplexRetinol + Emulsion 0.3

Brightening & Dark Spots

Brightening SerumActive SerumSuper Serum Advanced+

Redness & Sensitivity

Hydra-Cool SerumPro-Health Serum Advanced+Reparative Moisture Emulsion

Clarity & Texture

Active SerumActive Peel SystemCleansing Complex

How iS Clinical Compares

Where iS Clinical sits relative to other skincare tiers. Each has its place — the right fit depends on your skin and goals.

iS Clinical vs Other Skincare Tiers
iS ClinicalTypical DrugstoreLuxury Brand
ApproachBotanical bionutrient scienceMass-marketCosmetic
SignatureCult Active Serum & Super SerumNoneVaries
ActivesPlant-derived at clinical strengthLow OTC levelsVariable
Sold byAuthorized clinics & retailersOpen shelfCounters
At WeDoSkinAuthentic + 5% cashback——

iS Clinical: Frequently Asked Questions

Is WeDoSkin an authorized iS Clinical retailer in Canada?

Yes. WeDoSkin is a Preferred Authorized Retailer, so every iS Clinical product is authentic and sourced through authorized Canadian distribution.

What is iS Clinical known for?

iS Clinical is known for botanical, bionutrient-rich formulas — above all the cult Active Serum and Super Serum Advanced+, which are favourites among skincare professionals.

What does iS Clinical Active Serum do?

Active Serum is a fast-acting treatment that helps smooth texture, brighten tone, clear blemishes and soften fine lines using botanical acids and bionutrients. Many users notice visible results quickly.

Active Serum vs Super Serum Advanced+ — which should I choose?

Active Serum focuses on clarity, texture and blemishes, while Super Serum Advanced+ emphasises vitamin C brightening, hydration and anti-aging. Some people use Active Serum at night and Super Serum by day.

iS Clinical vs ZO Skin Health: which is better?

ZO Skin Health leans on pharmaceutical retinol and aggressive correction, while iS Clinical leans on botanical bionutrients. ZO is the more intensive resurfacing line; iS Clinical is elegant and botanical-forward.

iS Clinical vs AlumierMD: how do they compare?

AlumierMD emphasises clean, fragrance-free clinical formulas, while iS Clinical emphasises botanical actives and cult serums. Both are professional — the choice comes down to formula philosophy and which heroes you want.

iS Clinical vs SkinCeuticals: how do they differ?

SkinCeuticals is antioxidant- and patent-led (C E Ferulic), while iS Clinical is botanical-bionutrient-led (Active Serum). Both excel at antioxidant care — SkinCeuticals is more clinical, iS Clinical more botanical.

iS Clinical vs Vivier: which is better?

Vivier centres on its GrenzCine retinol-and-C complex, while iS Clinical centres on botanical serums. Vivier is potency-and-retinol forward; iS Clinical is botanical and multitasking.

Is iS Clinical worth it?

For people who want elegant, fast-acting botanical formulas with visible results, iS Clinical's cult serums are widely loved by professionals and clients — which is why they remain bestsellers year after year.

Is iS Clinical medical grade?

Yes. iS Clinical is a professional skincare line sold through authorized clinics and retailers, formulated with clinically meaningful concentrations of botanical and bioactive ingredients.

What are the best iS Clinical products for brightening?

The Brightening Serum, Active Serum and Super Serum Advanced+ are top choices for tone and dark spots. See our hyperpigmentation collection for more.

What are the best iS Clinical products for anti-aging?

For ageing skin, pair Super Serum Advanced+ with the Youth Complex and the Retinol + Emulsion. Explore our anti-aging range for a full routine.

What are the best iS Clinical products for sensitive or red skin?

The Hydra-Cool Serum and Pro-Health Serum Advanced+ are soothing, hydrating options well suited to reactive skin. See our redness & sensitivity collection.

How do I use iS Clinical Active Serum?

Apply a thin layer to clean skin once daily to start (often at night), building to twice daily as tolerated. Always follow with SPF during the day, as the botanical acids can increase sun sensitivity.

Does WeDoSkin ship iS Clinical across Canada?

Yes — we ship iS Clinical Canada-wide with fast dispatch, free samples, and 5% cashback on every order.

Where can I buy authentic iS Clinical in Canada?

Authentic iS Clinical is available in Canada at WeDoSkin, a Preferred Authorized Canadian Retailer, with verified sourcing, fresh stock and the full manufacturer guarantee.

Medically reviewed by Dr. J. Porter
Medical Reviewer, WeDoSkin Clinic

This page is maintained and reviewed by the WeDoSkin Clinical Team to ensure accuracy and alignment with iS Clinical's official guidance. WeDoSkin is a Preferred Authorized Retailer; all products are authentic and sourced through authorized Canadian distribution. Information is educational and not a substitute for professional medical advice.

Read about our medical-review standards →
Last reviewed March 18, 2026 · WeDoSkin Clinic, Calgary · Educational information, not a substitute for personalized medical advice.

Explore Related Concerns & Ingredients

The concern and ingredient hubs iS Clinical products most often appear in at WeDoSkin.

IngredientVitamin CBrighten & defendExplore →IngredientAntioxidantsBotanical defenseExplore →IngredientRetinolRenew & resurfaceExplore →ConcernAnti-AgingFirm & smoothExplore →BrandZO Skin HealthExplore the ZO rangeExplore →BrandAlumierMDExplore the AlumierMD rangeExplore →

Why Canadians Choose WeDoSkin

Trusted by more than 100,000 customers, WeDoSkin.ca is a Preferred Authorized Retailer of medical-grade skincare in Canada — 45+ professional brands and 3,000+ products, with cashback rewards that never expire, 100-day returns, free Canada-wide shipping over $65, and free samples in every order.

Authorized & AuthenticEvery product is sourced directly from the brand — never grey-market — with full manufacturer warranty.
100,000+ Happy CustomersA trusted Canadian destination for medical-grade skincare, with thousands of verified reviews on Trustpilot, Google and Judge.me.
Rewards That Never ExpireEarn 5–20% cashback with no dated points and no minimum to redeem — more rewarding than typical points programs.
100-Day ReturnsReturn unopened products for a full 100 days, or opened products for 45 days through BuySure.
Free Shipping Over $65Fast, Canada-wide delivery, with complimentary samples included in every order.
45+ Brands, 3,000+ ProductsFrom ZO Skin Health and SkinCeuticals to Vivier, AlumierMD and dozens more — plus complimentary clinical guidance.

Why shop with WeDoSkin →

Questions about iS Clinical?

Connect with a WeDoSkin clinical expert for a complimentary consultation.

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