Collection: SkinBetter Science

The Science of Skinbetter: Clinical Data vs. Traditional Skincare

Skinbetter Science® differentiates itself not through marketing, but through peer-reviewed biotechnology. Unlike traditional "doctor brands" that rely on high-percentage acids that cause downtime (redness and peeling), Skinbetter utilizes patented delivery systems (InterFuse®) and molecular conjugation (AlphaRet®) to achieve results comparable to prescription treatments without the associated irritation. At WeDoSkin.ca, we are an authorized Canadian stockist providing the full medical range.

1. Patented Technologies: Why It Works

Skinbetter Science holds dozens of patents. Understanding these technologies explains why the products justify their price point and efficacy.

AlphaRet® Technology (The Retinoid Revolution)

Standard retinol requires two conversion steps in the skin to become retinoic acid (the active form), which often causes irritation. Prescription Tretinoin is active immediately but causes severe dryness.

• The Innovation: AlphaRet is a patented molecule that chemically conjugates a retinoid to an Alpha Hydroxy Acid (AHA).
• The Result: It provides the visible rejuvenation of a prescription retinoid with the high tolerability of a moisturizer. The AHA hydrates and exfoliates while the retinoid renews collagen.[1]

InterFuse® Delivery System

Many skincare ingredients, like Hyaluronic Acid, are too large to penetrate the skin barrier effectively. InterFuse is a patented transdermal delivery system that transports large molecules faster and deeper.

• Application: Used in Intensive Treatment LINES, it drives high-molecular-weight injectable-grade hyaluronic acid deep into wrinkles to plump them from the inside out.[2]

WEL Technology (Antioxidant Defense)

Found in Alto Defense Serum, this technology combines Water, Enzymatic, and Lipid-soluble antioxidants. Most serums only protect against one type of free radical; WEL Technology provides 360-degree protection against environmental, blue light, and pollution damage.

2. Clinical Efficacy: AlphaRet® vs. Tretinoin

The core of the Skinbetter line is the AlphaRet technology. In a double-blind, split-face clinical study published in the Journal of Drugs in Dermatology, AlphaRet Overnight Cream was compared directly against prescription Tretinoin 0.025%.

• Efficacy: AlphaRet demonstrated comparable reduction in fine lines, erythema (redness), and dyschromia (pigmentation) to Tretinoin 0.025% after 12 weeks.[1]
• Tolerability: Subjects reported significantly less irritation, peeling, and dryness with AlphaRet compared to the Tretinoin/Retinol control group.

3. Comparison: Skinbetter Science vs. ZO Skin Health

This is the most common comparison in our clinic. Both are top-tier medical brands, but they serve different patient profiles.

4. How to Layer a Skinbetter Routine

Because the products are multi-tasking, a Skinbetter routine is often simpler than other medical grades. Here is the clinician-recommended order:

1. Cleanse: Cleansing Gel (Mild, foaming).
2. Treat (AM/PM): Alto Advanced Defense (Apply to dry skin).
3. Target (AM/PM): Even Tone Correcting Serum or Mystro.
4. Correct (PM ONLY): AlphaRet Overnight Cream.
5. Hydrate: Trio Rebalancing Moisture.
6. Protect (AM): Sunbetter® Tone Smart SPF.

5. Extensive Frequently Asked Questions (FAQ)