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Best Antioxidant Serums for Skin in Canada

Antioxidants neutralise the free radicals — from UV and pollution — that break down collagen and accelerate visible aging. The most effective way to use them is in a morning serum (vitamin C, vitamin E, ferulic acid, resveratrol) layered under SPF for compounding daytime defence. Shop medical-grade antioxidant skincare from professional brands including SkinCeuticals, ZO Skin Health, Vivier, iS Clinical and AlumierMD — authentic and authorized in Canada.

Vitamin CVitamin EResveratrolNiacinamide
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  • Vivier GrenzCine® Face Vivier GrenzCine® Face

    Vivier GrenzCine® Face

    $292.00
    $292.00
    $292.00
    Earn 5% Cashback
  • iS Clinical Youth Intensive Crème 100g iS Clinical Youth Intensive Crème 100g

    iS Clinical Youth Intensive Crème 100g

    $554.00
    $554.00
    $554.00
    Earn 5% Cashback
  • iS Clinical Brightening Complex iS Clinical Brightening Complex

    iS Clinical Brightening Complex

    $219.00
    $219.00
    $219.00
    Earn 5% Cashback
  • ZO Skin Health Body Emulsion ZO Skin Health Body Emulsion

    ZO Skin Health Body Emulsion

    $140.00
    $140.00
    Earn 5% Cashback
  • TiZO® Photoceutical AM Rejuvenation TiZO® Photoceutical AM Rejuvenation

    TiZO® Photoceutical AM Rejuvenation

    $116.45
    $116.45
    $85.00
    Earn 5% Cashback
  • PCA Skin Vitamin B3 Brightening Serum PCA Skin Vitamin B3 Brightening Serum
    $111.63 Off

    PCA Skin Vitamin B3 Brightening Serum

    $111.64
    $111.64
    $223.27
    Earn 5% Cashback
  • PCA Skin C&E Advanced with Hexylresorcinol PCA Skin C&E Advanced with Hexylresorcinol
    $72.50 Off

    PCA Skin C&E Advanced with Hexylresorcinol

    $72.50
    $72.50
    $145.00
    Earn 5% Cashback
  • GlyMed Vitamin C Cream GlyMed Vitamin C Cream

    GlyMed Vitamin C Cream

    $136.50
    $136.50
    $136.50
    Earn 5% Cashback
  • Esthederm Intensive Vitamine C Gel-Cream Esthederm Intensive Vitamine C Gel-Cream

    Esthederm Intensive Vitamine C Gel-Cream

    $110.00
    $110.00
    Earn 5% Cashback
  • PCA Skin C&E Strength Max PCA Skin C&E Strength Max
    $88.50 Off

    PCA Skin C&E Strength Max

    $88.50
    $88.50
    $177.00
    Earn 5% Cashback
  • GM Collin Nutriderm Cream GM Collin Nutriderm Cream

    GM Collin Nutriderm Cream

    $76.00
    $76.00
    Earn 5% Cashback
  • GM Collin Diamond Cream GM Collin Diamond Cream

    GM Collin Diamond Cream

    $300.00
    $300.00
    Earn 5% Cashback
  • YonKa Cream 93 YonKa Cream 93

    YonKa Cream 93

    $80.00
    $80.00
    Earn 5% Cashback
  • FOREO Green Tea Sheet Mask (3x) FOREO Green Tea Sheet Mask (3x)

    FOREO Green Tea Sheet Mask (3x)

    $27.90
    $27.90
    $27.90
    Earn 5% Cashback
  • FOREO Make My Day UFO™ Activated Mask FOREO Make My Day UFO™ Activated Mask

    FOREO Make My Day UFO™ Activated Mask

    $17.90
    $17.90
    $17.90
    Earn 5% Cashback
  • Alastin Restorative Neck Complex Alastin Restorative Neck Complex

    Alastin Restorative Neck Complex

    $182.00
    $182.00
    $182.00
  • iS Clinical GeneXC Serum iS Clinical GeneXC Serum

    iS Clinical GeneXC Serum

    $245.00
    $245.00
    $245.00
    Earn 5% Cashback
  • iS Clinical Youth Intensive Crème 50g iS Clinical Youth Intensive Crème 50g

    iS Clinical Youth Intensive Crème 50g

    $338.00
    $338.00
    $338.00
    Earn 5% Cashback
  • PCA Skin Intensive Age Refining Treatment PCA Skin Intensive Age Refining Treatment
    $87.00 Off

    PCA Skin Intensive Age Refining Treatment

    $87.00
    $87.00
    $174.00
    Earn 5% Cashback
  • Alastin C-RADICAL Defense Antioxidant Serum Alastin C-RADICAL Defense Antioxidant Serum

    Alastin C-RADICAL Defense Antioxidant Serum

    $218.00
    $218.00
    $218.00
  • Jan Marini Luminate Face Mask Jan Marini Luminate Face Mask

    Jan Marini Luminate Face Mask

    $148.00
    $148.00
    $148.00
    Earn 5% Cashback
  • Jan Marini C-Esta Face Serum Jan Marini C-Esta Face Serum

    Jan Marini C-Esta Face Serum

    $190.00
    $190.00
    $190.00
    Earn 5% Cashback
  • Jan Marini Age Intervention Peptide Extreme Jan Marini Age Intervention Peptide Extreme

    Jan Marini Age Intervention Peptide Extreme

    $190.00
    $190.00
    $190.00
    Earn 5% Cashback

The Complete Guide to Antioxidants

Antioxidants are your skin's daily defense against the free radicals from UV and pollution that drive premature ageing, dullness and dark spots. This guide covers the best antioxidant serums in Canada — from the classic vitamin C + E + ferulic trio to resveratrol and peptide-powered formulas.

Every antioxidant serum below is 100% authentic and shipped fast across Canada from WeDoSkin, a Preferred Authorized Retailer, with free samples and 5% cashback on every order.

🛡️

Neutralise Free Radicals

Antioxidants disarm the free radicals from UV and pollution that drive premature ageing.

☀️

Boost Your SPF

Worn in the morning under sunscreen, antioxidants add a second layer of daytime defense.

✨

Brighten & Even

Many antioxidants also fade dullness and even out tone for visible radiance.

🌿

Calm & Protect

Polyphenol antioxidants help soothe and protect stressed, reactive skin.

The Science Behind Antioxidants

How Antioxidants's key actives work — and why formulation and delivery matter as much as the ingredient itself.

VITAMIN C

Vitamin C

The hero antioxidant — it brightens, supports collagen and neutralises free radicals. Most potent when fresh and formulated at a low pH.

E + FERULIC

Vitamin E & Ferulic Acid

Lipid-soluble vitamin E and ferulic acid stabilise vitamin C and extend daytime protection — the classic C + E + ferulic trio.

RESVERATROL

Resveratrol & Polyphenols

Plant polyphenols like resveratrol and green tea add night-time antioxidant defense and help calm the skin.

SUPPORTING

Peptides & Niacinamide

Niacinamide and peptides round out antioxidant formulas, strengthening the barrier while defending against environmental stress.

These descriptions reflect how each ingredient category works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.

Antioxidants Bestsellers

The most-loved Antioxidants products at WeDoSkin. Tap any product to shop.

Alumier EverActive C&E™ + Peptide (3 Pack)Alumier EverActive C&E™ + Peptide (3 Pack)$230.00Shop now →SkinCeuticals C E Ferulic — New 2026 FormulaSkinCeuticals C E Ferulic — New 2026 Formula$230.00Shop now →Alumier Alumience A.G.E.™Alumier Alumience A.G.E.™$176.00Shop now →Alumier EverActive C&E + Peptide SingleAlumier EverActive C&E + Peptide Single$100.50Shop now →Alumier EvenToneAlumier EvenTone$140.00Shop now →Alumier Calm-R®Alumier Calm-R®$158.00Shop now →Alumier HydraDewAlumier HydraDew$88.50Shop now →

Shop the Full Antioxidants Range

Browse every Antioxidants product by category, with live Canadian pricing.

Antioxidants
PCA Skin C&E Advanced with Hexylresorcinol$72.50
Body Care
ZO Skin Health Body Emulsion$140.00Alastin Restorative Neck Complex$182.00
Masks & Peels
FOREO Green Tea Sheet Mask (3x)$27.90FOREO Make My Day UFO™ Activated Mask$17.90Jan Marini Luminate Face Mask$148.00
Moisturizers
Vivier GrenzCine® Face$292.00iS Clinical Youth Intensive Crème 100g$554.00TiZO® Photoceutical AM Rejuvenation$116.45GlyMed Vitamin C Cream$136.50Esthederm Intensive Vitamine C Gel-Cream$110.00GM Collin Nutriderm Cream$76.00GM Collin Diamond Cream$300.00YonKa Cream 93$80.00iS Clinical Youth Intensive Crème 50g$338.00Jan Marini Age Intervention Peptide Extreme$190.00
Retinols
iS Clinical Brightening Complex$219.00PCA Skin Intensive Age Refining Treatment$87.00
Serums, Oils & Concentrates
PCA Skin Vitamin B3 Brightening Serum$111.64PCA Skin C&E Strength Max$88.50iS Clinical GeneXC Serum$245.00Alastin C-RADICAL Defense Antioxidant Serum$218.00Jan Marini C-Esta Face Serum$190.00

How to Choose What's Right for You

New to Antioxidants? Start with your primary concern — here's where most people begin.

Best Overall Antioxidant Serums

EverActive C&E + PeptideSkinCeuticals C E FerulicAlumience A.G.E.

Best for Brightening

EvenToneEverActive C&E + PeptideC E Ferulic

Best for Sensitive & Redness

Calm-RHydraDewRecovery Balm

Best for Anti-Aging Night Defense

Alumience A.G.E.C E FerulicEverActive Single

Antioxidants: Frequently Asked Questions

What is the best antioxidant serum in Canada?

Top antioxidant serums include AlumierMD EverActive C&E + Peptide, SkinCeuticals C E Ferulic and Alumience A.G.E. The best one depends on whether you want fresh-activated vitamin C, a ready-to-use C+E+ferulic formula or a multi-antioxidant night serum.

What do antioxidants do for your skin?

Antioxidants neutralise free radicals generated by UV light and pollution. Left unchecked, those free radicals damage collagen and accelerate visible ageing, so a daily antioxidant helps protect against fine lines, dullness and dark spots.

Antioxidant serum vs vitamin C serum — what's the difference?

Vitamin C is the most popular antioxidant, so most vitamin C serums are antioxidant serums. But antioxidants also include vitamin E, ferulic acid, resveratrol and green tea — many of the best formulas combine several for broader protection.

When should I apply antioxidant serum, morning or night?

Morning is ideal, since antioxidants boost your daytime defense and work synergistically under sunscreen. Some polyphenol antioxidants like resveratrol are designed for night-time repair, so a few people use one of each.

What is the best antioxidant for anti-aging?

A well-formulated vitamin C + E + ferulic serum such as C E Ferulic or EverActive C&E + Peptide is the gold standard for anti-aging defense, ideally paired with retinol at night and daily SPF.

Can I use antioxidants with retinol?

Yes — most people use an antioxidant in the morning and retinol at night. This keeps each ingredient working at its best and minimises irritation.

Do antioxidants replace sunscreen?

No. Antioxidants complement sunscreen but don't replace it — think of them as a second layer of defense under your SPF. Always finish your morning routine with a broad-spectrum sunscreen.

What are the best antioxidants for sensitive skin?

Gentler antioxidant options like Calm-R, polyphenol-based formulas and barrier-supporting moisturisers tend to suit sensitive skin best. Introduce a potent vitamin C slowly if your skin is reactive.

Which antioxidants work best together?

Vitamin C, vitamin E and ferulic acid are a classic, well-studied combination — vitamin E and ferulic acid stabilise the vitamin C and extend its protective benefits.

How long do antioxidant serums take to work?

Antioxidant protection starts immediately, while visible brightening and a more even, radiant tone typically build over 4-12 weeks of consistent daily use.

Where can I buy authentic antioxidant skincare in Canada?

WeDoSkin is a Preferred Authorized Canadian Retailer for AlumierMD, SkinCeuticals, ZO Skin Health and more, so every antioxidant serum is authentic, fresh and shipped fast Canada-wide.

Medically reviewed by Dr. J. Porter
Medical Reviewer, WeDoSkin Clinic

This antioxidant guide is maintained and reviewed by the WeDoSkin Clinical Team. As a Preferred Authorized Canadian Retailer we handle these formulas every day and only list authentic, in-date stock. Information here is educational and not a substitute for personalized medical advice.

Read about our medical-review standards →
Last reviewed June 10, 2026 · WeDoSkin Clinic, Calgary · Educational information, not a substitute for personalized medical advice.

Explore Related Concerns & Ingredients

The concern and ingredient hubs Antioxidants products most often appear in at WeDoSkin.

IngredientVitamin CExplore →IngredientVitamin EExplore →IngredientResveratrolExplore →IngredientNiacinamideExplore →CategorySunscreensExplore →

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