NeoGenesis Intensive Moisturizer

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Intensive Moisturizer is the NeoGenesis cream for normal to dry skin, and the one skincare professionals reach for in dry climates and colder months.

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NeoGenesis Intensive Moisturizer (30mL)
NeoGenesis Intensive Moisturizer (120mL)
NeoGenesis Intensive Moisturizer (5mL)
  • NeoGenesis Intensive Moisturizer (30mL)
  • NeoGenesis Intensive Moisturizer (120mL)
  • NeoGenesis Intensive Moisturizer (5mL)
NeoGenesis Intensive Moisturizer (30mL)
NeoGenesis Intensive Moisturizer (120mL)
NeoGenesis Intensive Moisturizer (5mL)
  • Description

  • Key Benefits

  • How to use

  • Ingredients

  • Frequently Asked Questions

Description

Size: 5 mL / 30 mL / 120 mL

Skin Types: Normal, Dry, Sensitive Skin, Mature skin

Skin Concerns: Normal to dry skin, dry, dehydrated and depleted skin, mature skin and visible signs of aging, dry climates and colder months, skin that is stressed or compromised by professional treatments, reactive skin that needs lipid replenishment, skin that feels tight, rough or uncomfortable

Intensive Moisturizer is the NeoGenesis moisturizer for normal to dry skin, and the one to reach for in dry climates and colder months. It is powered by 5% S2RM, stem cell released molecules, a nourishing blend of growth factors, heat shock proteins, immune modulators and antioxidants that supports the skin's natural recovery and renewal processes and helps improve overall tone and texture. Dermatologist recommended and made for all skin types.


Around the S2RM sits a lipid-rich base: safflower oleosomes, squalane and triglycerides soften skin and reduce transepidermal water loss, urea, sodium hyaluronate and glycerin replenish hydration, and CoQ10 and vitamin E add antioxidant support. It deeply hydrates, replenishes the skin's oil levels, supports the barrier and comfort, and promotes a more youthful-looking complexion. Apply one pump morning and evening after your S2RM serum, plus one for neck and decollete. Available in 5 mL, 30 mL and 120 mL.

Watch: Intensive Moisturizer explained

NeoGenesis made this short product video for Intensive Moisturizer, so you can see the texture, the application and where it fits in a routine before you buy.

Real results with Intensive Moisturizer

NeoGenesis publishes before and after photos from its professional partners. These cases used Intensive Moisturizer as part of a NeoGenesis routine, and each caption lists every product involved.

Dark spots and uneven tone. Products used: Skin Serum, Intensive Moisturizer. Photos courtesy of Pamela Vendetti, Pamela V Skincare.

Dark spots and uneven tone. Products used: Skin Serum, Intensive Moisturizer.

Photos courtesy of Pamela Vendetti, Pamela V Skincare. Individual results vary.

Visible signs of aging, eye area. Products used: Skin Serum, Intensive Moisturizer. Photos courtesy of NeoGenesis.

Visible signs of aging, eye area. Products used: Skin Serum, Intensive Moisturizer.

Photos courtesy of NeoGenesis. Individual results vary.

Within 48 hours I could feel a real difference in the texture of my skin; it felt so soft and hydrated.Shared by NeoGenesis
Visible signs of aging, eye area. Products used: Skin Serum, Intensive Moisturizer. Photos courtesy of NeoGenesis.

Visible signs of aging, eye area. Products used: Skin Serum, Intensive Moisturizer.

Photos courtesy of NeoGenesis. Individual results vary.

Within 48 hours I could feel a real difference in the texture of my skin; it felt so soft and hydrated.Shared by NeoGenesis
Dark spots and uneven tone. Products used: Recovery, Intensive Moisturizer. Photos courtesy of NeoGenesis.

Dark spots and uneven tone. Products used: Recovery, Intensive Moisturizer.

Photos courtesy of NeoGenesis. Individual results vary.

Photos courtesy of NeoGenesis professional partners. Individual results vary.

Key Benefits

How to use

Ingredients

Frequently Asked Questions

Recommended Products

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Intensive Moisturizer: 5% S2RM for skin that needs real moisture

Intensive Moisturizer is the NeoGenesis cream for normal to dry skin, and the one skincare professionals reach for in dry climates and colder months. It is powered by 5% S2RM, stem cell released molecules from human fibroblast and adipose mesenchymal stem cells: a nourishing blend of growth factors, heat shock proteins, immune modulators and antioxidants that supports the skin's natural recovery and renewal processes and helps improve overall tone and texture. NeoGenesis calls this promoting skin longevity.

The base is where the moisture comes from. Safflower oleosomes, squalane and triglycerides soften skin and reduce transepidermal water loss, urea, sodium hyaluronate and glycerin replenish hydration, and CoQ10 and vitamin E add antioxidant support. Together they replenish the skin's oil levels, support the barrier and comfort, and hydrate and calm skin that is depleted, stressed or compromised by professional treatments. Apply one pump morning and evening after your S2RM serum, with an extra pump for neck and decollete.

🧬

5% S2RM inside

Growth factors, heat shock proteins, immune modulators and antioxidants that support recovery, renewal, tone and texture.

✨

Rich moisture for dry skin

Replenishes the skin's oil levels and supports comfort and resilience, even in dry climates and cold weather.

💧

Calms compromised skin

Hydrates and calms skin that is depleted of moisture, stressed or compromised by professional treatments.

🛡️

Lipids without grease

Safflower oleosomes, squalane and triglycerides soften skin and reduce water loss while feeling comfortable, not heavy.

Key Ingredients & How They Work

The actives that drive 5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin. — and what each one does for your skin.

S2RM MOISTURIZER

S2RM in a moisturizer

Human fibroblast and adipose mesenchymal stem cell conditioned media, at 5%, delivers the stem cell released molecules NeoGenesis is known for, so the moisturizer supports renewal rather than just coating the surface.

OLEOSOMES SQUALANE

Oleosomes and squalane

Safflower oil oleosomes, squalane and caprylic/capric triglyceride replenish lipids and reduce transepidermal water loss (TEWL), leaving skin soft and comfortable without a greasy finish.

LAYERED HYDRATION

Layered hydration

Urea, glycerin and high molecular weight sodium hyaluronate work together to replenish water in the skin and improve texture, backed by chondrus crispus (red algae) extract.

COQ10 VITAMIN

CoQ10 and vitamin E

Ubiquinone replenishes the skin's CoQ10 to help energize cells and provide antioxidant support, while tocopheryl acetate adds further antioxidant protection for skin longevity.

These descriptions reflect how each ingredient works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.

Benefits of 5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin.

Deeply hydrates and nourishes normal to dry skin
Replenishes the skin's oil levels and essential lipids
Supports the skin barrier, comfort and resilience
Hydrates and calms depleted, stressed or compromised skin
Improves overall tone and texture with 5% S2RM
Promotes a softer, smoother, more youthful-looking complexion

What 5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin. Pairs Well With

Build a complete routine — these pairings are most often recommended alongside 5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin.. Tap any product to shop.

How to Use

  1. Cleanse, then apply your S2RM serum (Recovery, Booster or Skin Serum).
  2. Apply 1 pump of Intensive Moisturizer to the face morning and evening, and an additional pump to the neck and decollete.
  3. Follow with sunscreen during the day. Many people favor it in the evening, when skin goes through its natural overnight renewal.

Who It's For

  • Normal to dry skin, especially in dry climates and colder months
  • Mature skin with visible signs of aging that wants lipid replenishment and S2RM support
  • Dehydrated or environmentally stressed skin that feels tight, rough or depleted
  • Skin that is stressed or compromised by professional treatments and needs comfort and calm

Sensitivity note: Made for all skin types and positioned by NeoGenesis for compromised, stressed and reactive skin as well as dry skin. If your skin is oily or combination, the lighter NeoGenesis Light Moisturizer may be the better fit; if the barrier is the main concern, see Barrier Renewal Cream.

How 5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin. Compares

Where 5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin. sits relative to other options. The right fit depends on your skin and goals.

5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin. vs the Alternatives
FeatureNeoGenesis Intensive MoisturizerProfessional MoisturizersDrugstore Moisturizers
Active technology5% S2RM: growth factors, heat shock proteins, immune modulators, antioxidantsPeptides or a single growth factorNone, hydrators only
Lipid replenishmentSafflower oleosomes, squalane and triglycerides, non-greasyVaries by formulaOften mineral oil or heavy occlusives
HydrationUrea, glycerin and high molecular weight hyaluronic acidUsually hyaluronic acid aloneGlycerin, sometimes hyaluronic acid
Who it suitsDry, mature, dehydrated and compromised skin, all skin typesVariesVaries, often fragranced

5% S2RM in a rich, lipid-replenishing cream for dry, aging and compromised skin.: Frequently Asked Questions

What is NeoGenesis Intensive Moisturizer?

It is the NeoGenesis moisturizer for normal to dry skin, designed to deeply hydrate, replenish essential lipids and support skin that looks and feels at its best. Powered by 5% S2RM technology, it restores comfort, improves softness and promotes long-lasting hydration for dry, mature and environmentally stressed skin.

Is Intensive Moisturizer good for dry skin and dry climates?

Yes, that is exactly what NeoGenesis built it for. It provides rich moisture that replenishes the skin's oil levels and supports comfort and resilience, and the brand recommends it especially in colder months, in dry climates, or whenever skin feels tight, rough or depleted.

What makes Intensive Moisturizer different from other rich creams?

Most rich moisturizers simply coat the skin's surface. Intensive Moisturizer combines safflower oleosomes, squalane, urea, sodium hyaluronate, CoQ10 and vitamin E with regenerative 5% S2RM technology, so it hydrates and replenishes lipids while supporting the skin's natural recovery and renewal for a softer, smoother complexion.

Intensive Moisturizer or Barrier Renewal Cream: which do I need?

Intensive Moisturizer is formulated for dry, mature and dehydrated skin that needs long-lasting hydration and lipid replenishment. Barrier Renewal Cream is formulated for compromised, sensitized and post-procedure skin where restoring barrier function is the primary goal. If dryness is the main issue, start here.

Should I use Intensive Moisturizer in the morning or at night?

Either, or both, depending on your skin's hydration needs. NeoGenesis notes that many people enjoy it in the evening to replenish moisture while the skin goes through its natural overnight renewal. In the morning, follow it with sunscreen.

How do I use Intensive Moisturizer with the NeoGenesis serums?

Cleanse, apply your S2RM serum (Recovery, Booster or Skin Serum), then apply one pump of Intensive Moisturizer to the face and an additional pump to the neck and decollete. Use morning and evening, with sunscreen during the day. NeoGenesis also pairs it with Moisturizing Mist and MB-2 Probiotic Balm.

Are there before and after photos for Intensive Moisturizer?

Yes. NeoGenesis publishes before and after case photos from its professional partners, and a selection that used Intensive Moisturizer is shown above with every product in the routine listed in the caption. Individual results vary.

Is there a video on how to use Intensive Moisturizer?

Yes. The NeoGenesis product video above walks through Intensive Moisturizer, what is in it and how to apply it, and the science video explains the stem cell released molecules behind the line.

Medically reviewed by Dr. J. Porter
Medical Reviewer, WeDoSkin Clinic

This page is reviewed under the medical oversight of the WeDoSkin Clinic in Calgary. As a Preferred Authorized Retailer, our clinical team works directly with these brands and handles these formulas every day. Information here is educational and not a substitute for personalized medical advice.

Last reviewed March 18, 2026 · WeDoSkin Clinic, Calgary · Educational information, not a substitute for personalized medical advice.

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