NeoGenesis Review (2026): S2RM Stem Cell Released Molecule Skincare, Explained for Canada

Here is the uncomfortable truth about most regenerative serums: they hand your skin one word and expect it to understand the sentence. A single growth factor, maybe two, at a concentration the label will not disclose, and a story about collagen. Skin does not work on single words. Cells talk in paragraphs, hundreds of signalling molecules released at once.

That is the idea NeoGenesis built its line on. It cultures human fibroblast and adipose mesenchymal stem cells, collects everything they release (growth factors, peptides, cytokines, antioxidants and the extracellular vesicles we now call exosomes), and puts that complete secretome in the bottle. It calls this patented approach S2RM, stem cell released molecules, and prints the percentage on the label: 70, 40, 20 or 10. The products contain conditioned media, the molecules the cells released, not the cells themselves. The Recovery serum has seven ingredients, and the first two are that secretome.

So this is the honest version. What S2RM actually is, why the percentage ladder matters more than any claim, how NeoGenesis sits next to AnteAGE on the same shelf, the eight products worth buying in Canada with CAD prices, and real before and after photos the brand shared with us. WeDoSkin is an Authorized NeoGenesis Retailer in Canada; the full collection is here, and we are writing from the ingredient lists and the brand's own research titles.

What S2RM Actually Is (and What It Is Not)

The secretome, not the stem cell

Let us clear up the name, because "stem cell skincare" has been abused for fifteen years, usually by apple extracts. There are no stem cells in a NeoGenesis bottle. What is in there is conditioned media: the liquid that human fibroblast and adipose mesenchymal stem cells were cultured in, carrying everything those cells released. The ingredient list says it plainly: Human Adipose Mesenchymal Stem Cell Conditioned Media, Human Fibroblast Conditioned Media.

Why two cell types? Fibroblasts are the skin's own structural cells, the ones that make collagen and elastin. Adipose mesenchymal stem cells are the body's general-purpose support crew, known in research for the breadth of what they secrete. Together they give a wider molecular vocabulary than either alone, what the brand calls the complete molecular profile skin uses to communicate.

Growth factors, exosomes and the rest of the alphabet

We have ranked both growth factor serums and exosome serums. NeoGenesis sits in a different place: it is the whole secretome, which contains both. Growth factors and structural proteins for the look of firmness. Tyrosinase-modulating proteins and antioxidants for even tone. Heat shock proteins and immune-supporting signalling molecules for skin that looks calmer. Matrix proteins and peptides for resilience. Those are the brand's own groupings, and they map onto the before and after cases further down.

Video: Understanding stem cells in NeoGenesis products, a science presentation by NeoGenesis.

NeoGenesis publishes research titles on its product pages (Systems Therapeutics Approach, Rescue of Degenerating Cells Using S2RM, Safety Profile of S2RM Technology, Physiological Renormalization of Skin) and shared a proteomic analysis of its secretome with us. We will not quote numbers from it here, but it exists, which is more than most "stem cell" brands can say.

Clinically tested, dermatologist recommended, and the doctor behind it

Two facts the brand states are worth knowing. NeoGenesis describes its serums as clinically tested and dermatologist recommended, and it names Dr. Raja Sivamani, a dermatologist, as Head of its Scientific Medical Advisory Board. These are brand statements, but a regenerative company that puts a dermatologist's name on its science is behaving differently from one that hides behind a logo. The formulas are also short, fragrance free, pH adjusted to match the skin's own acidity, and made for all skin types including sensitive and reactive skin.

The 70/40/20/10 Ladder: Why the Percentage Is the Product

This is the part most reviews skip, and the part that saves you money. NeoGenesis makes four S2RM serums, and the difference between them is almost entirely how much secretome is in the bottle. Pick by how much support your skin needs, not by which has the nicest name.

70%: Recovery, for skin that needs the most help

Recovery is the highest concentration and the simplest formula: the two conditioned media, water, a thickener, a preservative system and a touch of lactic acid for pH. NeoGenesis positions it for aging, chronic and acute concerns: the look of lines, dark spots and uneven tone, visible redness, congestion in blemish-prone skin, and skin stressed after professional treatments. It is the serum in the post-procedure cases the brand publishes, applied right after microneedling and microcurrent. From $100 for 5 mL.

40%: Booster, for hydration and age management in one

Booster trades some secretome for a supporting cast: sodium hyaluronate butyrate (a hyaluronic acid the brand describes as a cellular energy source), silk amino acids, baobab seed extract and rose geranium water. It feels like it is doing something the moment it goes on, which the 70% does not, while still carrying a serious S2RM dose. If dryness, tightness and early crepiness are your complaints, this beats Recovery. From $80 for 5 mL.

20%: Skin Serum, the daily essential and the body serum

Skin Serum is where the brand sends younger skin, early signs of aging, dry sensitive skin and dry redness-prone skin. It is also the most practical product in the line, because it comes in 120 mL and NeoGenesis recommends it for the chest, back, hands and arms. A 70% serum on your décolleté is a luxury; a 20% serum there is a routine. From $55 for 5 mL.

10%: Eye Serum, the delicate-area step

Eye Serum drops to 10% S2RM and adds what eye products need: hesperidin methyl chalcone and chrysin for the look of dark circles and puffiness, three peptides for the look of lines, and sodium hyaluronate butyrate for hydration. Apply around both eyes and over the lips, morning and evening, after your S2RM serum. From $55 for 5 mL.

The rest of the line, Intensive Moisturizer at 5% S2RM and the S2RM-free supporting products, exists to seal and complement the serums. NeoGenesis also makes hair, brow and lash serums on a sibling technology called S3RM, which adds dermal papilla progenitor cells to the fibroblast and adipose cells. Those are a different article; find them in the NeoGenesis collection.

NeoGenesis vs AnteAGE: Two Regenerative Brands, One Shelf

Where they overlap

If you have read our AnteAGE MD Intensify review, you know AnteAGE is the other regenerative brand we stock that is built on stem cell derived signalling rather than a single active. Both are professional lines used in clinics around procedures, both put the secretome, growth factors and exosomes at the centre, and both live in our advanced regenerative skincare collection.

Where they differ, and how to choose

The difference is philosophy. NeoGenesis is minimalist and transparent about dose: short formulas, the S2RM percentage on the label, and a ladder you climb or descend. AnteAGE builds layered systems around its growth factor and biosome technology, with more supporting actives per bottle. If you want to know exactly how much regenerative material you are paying for and like a formula you can read in one breath, NeoGenesis. If you want a fuller engineered system with brightening, barrier and eye steps built in, AnteAGE. Plenty of clinics use both.

The #1 Pick: NeoGenesis Recovery

The Power 8: Every NeoGenesis Product Worth Buying in Canada

Ranked by how we would build a routine from scratch, with live Canadian pricing on the entry size. Nobody needs all eight; the routines below show you which three or four you do.

1 · The 70% Flagship

NeoGenesis Recovery

The hero and the foundation of the line: 70% stem cell released molecules in a seven-ingredient formula. NeoGenesis positions it for skin that needs the most support, from the look of lines and dark spots to visible redness and skin stressed after a professional treatment, and it can be applied up to four times a day. From $100 for 5 mL.

$100.00Shop →

2 · The 40% All-Rounder

NeoGenesis Booster

Forty percent S2RM plus sodium hyaluronate butyrate and silk amino acids, so it hydrates on the spot while the secretome works on the look of firmness and uneven tone. The one NeoGenesis serum that does hydration and age management in a single step. From $80 for 5 mL.

$80.00Shop →

3 · The 20% Daily Essential

NeoGenesis Skin Serum

Twenty percent S2RM in a lightweight serum with glycerin and gluconolactone. NeoGenesis recommends it for younger skin, early signs of aging, dry redness-prone skin and, cleverly, for the chest, hands and arms, which is why a 120 mL size exists. From $55 for 5 mL.

$55.00Shop →

4 · The 10% Eye and Lip Step

NeoGenesis Eye Serum

Ten percent S2RM with hesperidin methyl chalcone and three peptides for the look of crow's feet, puffiness, dark circles and lip lines. Applied morning and evening over your S2RM serum. From $55 for 5 mL.

$55.00Shop →

5 · The Gentle Vitamin A

NeoGenesis Skin Restore Serum

No S2RM here: this is the vitamin A step, built on hydroxypinacolone retinoate with carotenoids, sunflower seed oil and squalane. Designed to follow the S2RM serums, and tolerated by most people without the usual flaking drama. From $40 for 5 mL.

$40.00Shop →

6 · The Compromised-Skin Cream

NeoGenesis Barrier Renewal Cream

Three skin-identical ceramides, cholesterol and free fatty acids, safflower oleosomes, urea and sodium PCA. Non-comedogenic, and the cream NeoGenesis points to for sensitive, sensitized or post-procedure skin. From $35 for 5 mL.

$35.00Shop →

7 · The Dry-Climate Moisturizer

NeoGenesis Intensive Moisturizer

The rich one, and the only moisturizer in the line with S2RM in it (5%). Safflower oleosomes, squalane, urea, hyaluronic acid, vitamin E and CoQ10 for normal to dry skin in dry climates. Prairie winters, this is your cream. From $30 for 5 mL.

$30.00Shop →

8 · The Quiet First Step

NeoGenesis Cleanser

A pH-balanced hydrating gel with glycerin and panthenol that removes makeup and sunscreen without stripping. It doubles as a body wash and a gentle shampoo, which sounds like a gimmick until you travel with one bottle. From $30 for 30 mL.

$30.00Shop →

Browse the full NeoGenesis collection for larger sizes, the Recovery spray, mists, masks and the S3RM hair, brow and lash serums.

Recovery vs Booster vs Skin Serum: The Three Serums People Cross-Shop

The three face serums most people are deciding between, side by side. There is no wrong choice, only a wrong dose for your skin.

The verdict: Recovery when your skin needs the most support or is recovering from a treatment. Booster when dryness and early aging are the complaint. Skin Serum when you are younger, redness-prone, on a budget, or want S2RM on your body. Buying all three is the mistake; buy the rung that matches your skin.

Four NeoGenesis Routines, Depending on Your Skin

The order never changes: cleanse, S2RM serum on damp skin, any other serum, then moisturizer and sunscreen immediately.

Five Mistakes That Waste a $100 Serum

1. Putting S2RM on after your other serums

Every NeoGenesis instruction starts the same way: after cleansing, apply the S2RM serum first, on damp skin, then everything else. Layering it over a vitamin C or a hyaluronic serum puts a barrier between the secretome and your skin. First means first.

2. Buying 70% when 20% was the right rung

Recovery is the flagship, not automatically the right choice. Under thirty with early lines, or covering your chest and hands? Skin Serum does the job at a fraction of the cost per application. The ladder exists so you can match the dose to the need.

3. Letting it dry without a moisturizer on top

NeoGenesis is emphatic: follow immediately with moisturizer and/or sunscreen. The serums are water-based and almost oil-free, designed to be sealed in. Skip the cream and you lose the point.

4. Judging it at week two

Hydration you can feel on day one, especially with Booster. The look of firmness, tone and texture follows the skin's own renewal timeline, measured in weeks. The brand's before and after cases are not day-two photos.

5. Starting Skin Restore Serum the same week as a procedure

The vitamin A step is gentle, but freshly treated skin wants S2RM and barrier support, not a retinoid. Run Recovery and Barrier Renewal Cream alone for the first week or two, follow your provider, and bring Skin Restore back when the skin has settled.

Real Results: NeoGenesis Before and After Photos

NeoGenesis publishes before and after cases from its clinic partners and shared them with us as an Authorized Canadian Retailer. These six were chosen because, between them, they use every product on this page. Captions are the brand's; we have not added a claim. Individual results vary, and each person was also following a skincare professional's guidance.

Photos courtesy of NeoGenesis and its clinic partners as credited. Unretouched case photos shared by the brand; individual results vary.

Across the full set of cases, Recovery is almost always in the routine, the moisturizer changes with the skin type (Intensive for dry, Barrier Renewal for sensitized), and the post-procedure cases are where the brand's professional heritage shows most clearly.

Frequently Asked Questions

Keep Reading