Category Spotlight · Authorized Canadian Retailer

Best Medical-Grade Serums in Canada

Serums are the treatment engine of a routine, delivering high concentrations of actives like vitamin C, retinol, peptides and hyaluronic acid deep into the skin. The best approach is to layer a targeted serum after cleansing and before moisturiser, choosing actives matched to your main concern. Shop medical-grade serums and facial oils from professional brands including SkinCeuticals, AlumierMD, Vivier, ZO Skin Health and iS Clinical — authentic and authorized in Canada.

  • Preferred Authorized Retailer
  • 100,000+ Happy Customers
  • Earn 5% Cashback
  • 100-Day Returns*
  • Free Samples

Showing 143 of 143 products

Sort by:
Brand
0 selected Reset
Product type
0 selected Reset
Filter and sort

Filter and sort

143 products

Brand
Product type
143 products
  • SkinCeuticals Phyto Corrective Gel
    SkinCeuticals Phyto Corrective Gel SkinCeuticals Phyto Corrective Gel

    SkinCeuticals Phyto Corrective Gel

    Regular price
    $115.00
    Sale price
    $115.00
    Regular price
    $115.00
    Earn 5% Cashback
    All Products
  • SkinCeuticals Hydrating B5 Gel
    SkinCeuticals Hydrating B5 Gel SkinCeuticals Hydrating B5 Gel

    SkinCeuticals Hydrating B5 Gel

    Regular price
    $125.00
    Sale price
    $125.00
    Regular price
    $125.00
    Earn 5% Cashback
    All Products
  • iS Clinical Retinol + Emulsion 0.3
    iS Clinical Retinol + Emulsion 0.3 iS Clinical Retinol + Emulsion 0.3

    iS Clinical Retinol + Emulsion 0.3

    Regular price
    $149.00
    Sale price
    $149.00
    Regular price
    $149.00
    Earn 5% Cashback
    All Products
  • iS Clinical Active Serum
    iS Clinical Active Serum iS Clinical Active Serum

    iS Clinical Active Serum

    Regular price
    $204.00
    Sale price
    $204.00
    Regular price
    $204.00
    Earn 5% Cashback
    All Products
  • iS Clinical Hydra-Cool Serum
    iS Clinical Hydra-Cool Serum iS Clinical Hydra-Cool Serum

    iS Clinical Hydra-Cool Serum

    Regular price
    $142.00
    Sale price
    $142.00
    Regular price
    $142.00
    Earn 5% Cashback
    All Products
  • ZO Skin Health Illuminating AOX Serum
    ZO Skin Health Illuminating AOX Serum ZO Skin Health Illuminating AOX Serum

    ZO Skin Health Illuminating AOX Serum

    Regular price
    $235.00
    Sale price
    $235.00
    Regular price
    Earn 5% Cashback
    All Products
  • iS Clinical Pro-Health Serum Advanced+
    iS Clinical Pro-Health Serum Advanced+ iS Clinical Pro-Health Serum Advanced+

    iS Clinical Pro-Health Serum Advanced+

    Regular price
    $226.00
    Sale price
    $226.00
    Regular price
    $226.00
    Earn 5% Cashback
    All Products
  • Epicutis Lipid Serum
    Epicutis Lipid Serum Epicutis Lipid Serum

    Epicutis Lipid Serum

    Regular price
    $300.00
    Sale price
    $300.00
    Regular price
    Earn 5% Cashback
    All Products
  • BABOR 10D Hyaluronic Acid Ampoule Serum Concentrate
    BABOR 10D Hyaluronic Acid Ampoule Serum Concentrate BABOR 10D Hyaluronic Acid Ampoule Serum Concentrate

    BABOR 10D Hyaluronic Acid Ampoule Serum Concentrate

    Regular price
    $54.76
    Sale price
    $54.76
    Regular price
    $39.97
    Earn 5% Cashback
    All Products
  • BABOR Radiance Ampoule Serum Concentrate
    BABOR Radiance Ampoule Serum Concentrate BABOR Radiance Ampoule Serum Concentrate

    BABOR Radiance Ampoule Serum Concentrate

    Regular price
    $65.00
    Sale price
    $65.00
    Regular price
    $65.00
    Earn 5% Cashback
    All Products
  • YonKa Advanced Optimizer Serum
    YonKa Advanced Optimizer Serum YonKa Advanced Optimizer Serum

    YonKa Advanced Optimizer Serum

    Regular price
    $142.00
    Sale price
    $142.00
    Regular price
    Earn 5% Cashback
    All Products
  • COOLA Dew Good Illuminating Serum Sunscreen with Probiotic Technology SPF 30
    COOLA Dew Good Illuminating Serum Sunscreen with Probiotic Technology SPF 30 COOLA Dew Good Illuminating Serum Sunscreen with Probiotic Technology SPF 30

    COOLA Dew Good Illuminating Serum Sunscreen with Probiotic Technology SPF 30

    Regular price
    $81.00
    Sale price
    $81.00
    Regular price
    Earn 5% Cashback
    All Products
  • ZO Skin Health Rozatrol
    ZO Skin Health Rozatrol ZO Skin Health Rozatrol

    ZO Skin Health Rozatrol

    Regular price
    From $62.00
    Sale price
    From $62.00
    Regular price
    Earn 5% Cashback
    All Products
  • Vivier Ultimage™
    Vivier Ultimage™ Vivier Ultimage™

    Vivier Ultimage™

    Regular price
    $166.00
    Sale price
    $166.00
    Regular price
    $166.00
    Earn 5% Cashback
    All Products
  • iS Clinical Youth Eye Complex
    iS Clinical Youth Eye Complex iS Clinical Youth Eye Complex

    iS Clinical Youth Eye Complex

    Regular price
    $144.50
    Sale price
    $144.50
    Regular price
    $144.50
    Earn 5% Cashback
    All Products
  • XYON Defend Hair & Scalp Serum for Men
    XYON Defend Hair & Scalp Serum for Men

    XYON Defend Hair & Scalp Serum for Men

    Regular price
    $72.00
    Sale price
    $72.00
    Regular price
    Earn 5% Cashback
    All Products
  • SkinBetter Alto Advanced Defense and Repair Serum
    SkinBetter Alto Advanced Defense and Repair Serum SkinBetter Alto Advanced Defense and Repair Serum

    SkinBetter Alto Advanced Defense and Repair Serum

    Regular price
    $290.00
    Sale price
    $290.00
    Regular price
    $290.00
    Earn 5% Cashback
    All Products
  • SkinBetter AlphaRet Clearing Serum
    SkinBetter AlphaRet Clearing Serum SkinBetter AlphaRet Clearing Serum

    SkinBetter AlphaRet Clearing Serum

    Regular price
    $220.00
    Sale price
    $220.00
    Regular price
    $220.00
    Earn 5% Cashback
    All Products
  • BABOR Rejuvenation Ampoule Serum Concentrate
    BABOR Rejuvenation Ampoule Serum Concentrate BABOR Rejuvenation Ampoule Serum Concentrate

    BABOR Rejuvenation Ampoule Serum Concentrate

    Regular price
    $65.00
    Sale price
    $65.00
    Regular price
    $65.00
    Earn 5% Cashback
    All Products
  • GM Collin Ceramide Comfort Serum - 80 Capsules
    GM Collin Ceramide Comfort Serum - 80 Capsules GM Collin Ceramide Comfort Serum - 80 Capsules

    GM Collin Ceramide Comfort Serum - 80 Capsules

    Regular price
    $142.00
    Sale price
    $142.00
    Regular price
    Earn 5% Cashback
    All Products
  • GM Collin Ceramide Comfort Serum - 20 Capsules
    GM Collin Ceramide Comfort Serum - 20 Capsules GM Collin Ceramide Comfort Serum - 20 Capsules

    GM Collin Ceramide Comfort Serum - 20 Capsules

    Regular price
    $40.00
    Sale price
    $40.00
    Regular price
    Earn 5% Cashback
    All Products
  • Colorescience Total Eye® Concentrate Serum Rollerball
    Colorescience Total Eye® Concentrate Serum Rollerball Colorescience Total Eye® Concentrate Serum Rollerball

    Colorescience Total Eye® Concentrate Serum Rollerball

    Regular price
    $98.00
    Sale price
    $98.00
    Regular price
    $98.00
    Earn 5% Cashback
    All Products
  • Vivier Radiance Serum
    Vivier Radiance Serum Vivier Radiance Serum

    Vivier Radiance Serum

    Regular price
    $181.00
    Sale price
    $181.00
    Regular price
    $181.00
    Earn 5% Cashback
    All Products

The Complete Guide to Serums & Oils

Serums are where visible change happens, delivering potent, targeted actives, antioxidants, retinol, peptides and brighteners, in concentrations creams cannot match. WeDoSkin carries medical-grade serums and oils from the professional brands clinics trust.

Browse best-selling serums below with live Canadian pricing, organised so you can find the right active for your concern.

🧪

High-Potency Actives

Concentrated vitamin C, retinol, peptides and growth factors.

🎯

Targeted Treatment

Choose a serum by concern: aging, pigment, redness or hydration.

🪶

Layer-Friendly

Lightweight textures absorb fast and layer under moisturiser.

🇨🇦

Authorized & Authentic

Fresh, correctly stored, sourced directly from the manufacturer.

The Science Behind Serums & Oils

How Serums & Oils's key actives work — and why formulation and delivery matter as much as the ingredient itself.

AM

Antioxidant Serums

Morning vitamin C and antioxidant serums defend against daytime free radicals.

PM

Retinol & Renewal

Evening retinol and resurfacing serums drive cell turnover while you sleep.

Hydrate

Hyaluronic & Soothing

Hydrating and calming serums layer with actives to support the barrier.

These descriptions reflect how each ingredient category works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.

Serums & Oils Bestsellers

The most-loved Serums & Oils products at WeDoSkin. Tap any product to shop.

Shop the Full Serums & Oils Range

Browse every Serums & Oils product by category, with live Canadian pricing.

How to Choose What's Right for You

New to Serums & Oils? Start with your primary concern — here's where most people begin.

Serums & Oils: Frequently Asked Questions

What does a face serum do?

A face serum delivers a high concentration of active ingredients, like vitamin C, retinol or hyaluronic acid, deep into the skin to target specific concerns more powerfully than a moisturizer.

In what order do I apply serums?

Apply serums after cleansing and before moisturizer, from thinnest to thickest texture. A common approach is an antioxidant serum in the morning and a retinol or treatment serum at night.

Can I use more than one serum?

Yes, but layer thoughtfully. Water-based serums go before oil-based ones, and some actives like vitamin C and retinol are often split between morning and night to reduce irritation.

What is the best anti-aging serum?

For aging, vitamin C serums like SkinCeuticals C E Ferulic protect by day and retinol serums renew by night. Peptide and growth-factor serums add firmness. The best choice depends on your skin's tolerance and goals.

Are facial oils good for oily skin?

Certain lightweight, non-comedogenic oils can balance oily skin, but those prone to congestion often prefer gel serums. Patch-test and introduce oils gradually.

How long until a serum shows results?

Hydrating serums work immediately, while treatment serums like retinol and vitamin C typically show visible results over 8 to 12 weeks of consistent use.

Medically reviewed by Dr. J. Porter
Medical Reviewer, WeDoSkin Clinic

Serum guidance here reflects standard dermatological principles on active ingredients and layering. As a Preferred Authorized Retailer, WeDoSkin stores and ships every formula correctly so actives stay potent. This is educational and not a substitute for personalized medical advice.

Last reviewed June 10, 2026 · WeDoSkin Clinic, Calgary · Educational information, not a substitute for personalized medical advice.

Explore Related Concerns & Ingredients

The concern and ingredient hubs Serums & Oils products most often appear in at WeDoSkin.

Why Canadians Choose WeDoSkin

Trusted by more than 100,000 customers, WeDoSkin.ca is a Preferred Authorized Retailer of medical-grade skincare in Canada — 45+ professional brands and 3,000+ products, with cashback rewards that never expire, 100-day returns, free Canada-wide shipping over $65, and free samples in every order.

Authorized & AuthenticEvery product is sourced directly from the brand — never grey-market — with full manufacturer warranty.
100,000+ Happy CustomersA trusted Canadian destination for medical-grade skincare, with thousands of verified reviews on Trustpilot, Google and Judge.me.
Rewards That Never ExpireEarn 5–20% cashback with no dated points and no minimum to redeem — more rewarding than typical points programs.
100-Day ReturnsReturn unopened products for a full 100 days, or opened products for 45 days through BuySure.
Free Shipping Over $65Fast, Canada-wide delivery, with complimentary samples included in every order.
45+ Brands, 3,000+ ProductsFrom ZO Skin Health and SkinCeuticals to Vivier, AlumierMD and dozens more — plus complimentary clinical guidance.

Why shop with WeDoSkin →

Questions about Serums & Oils?

Connect with a WeDoSkin clinical expert for a complimentary consultation.

Contact Our Skincare Experts