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Best Medical-Grade Serums in Canada

Serums are the treatment engine of a routine, delivering high concentrations of actives like vitamin C, retinol, peptides and hyaluronic acid deep into the skin. The best approach is to layer a targeted serum after cleansing and before moisturiser, choosing actives matched to your main concern. Shop medical-grade serums and facial oils from professional brands including SkinCeuticals, AlumierMD, Vivier, ZO Skin Health and iS Clinical — authentic and authorized in Canada.

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  • Alumier Enzymatic Peel
    Alumier Enzymatic Peel Alumier Enzymatic Peel

    Alumier Enzymatic Peel

    Regular price
    $129.00
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    $129.00
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    AHAs (Glycolic Acid/Lactic Acid)
  • Teoxane RHA Vitamin C Serum
    Teoxane RHA Vitamin C Serum Teoxane RHA Vitamin C Serum

    Teoxane RHA Vitamin C Serum

    Regular price
    $230.00
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    $230.00
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    $230.00
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  • ZO Skin Health Radical Night Repair
    ZO Skin Health Radical Night Repair ZO Skin Health Radical Night Repair

    ZO Skin Health Radical Night Repair

    Regular price
    $240.00
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    $240.00
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  • Vivier Serum 10
    Vivier Serum 10 Vivier Serum 10

    Vivier Serum 10

    Regular price
    $130.00
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    $130.00
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    $130.00
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  • Vivier Advanced Skin Lightening Serum
    Vivier Advanced Skin Lightening Serum Vivier Advanced Skin Lightening Serum

    Vivier Advanced Skin Lightening Serum

    Regular price
    $194.00
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    $194.00
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    $194.00
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  • Vivier QuintiSerum™
    Vivier QuintiSerum™ Vivier QuintiSerum™

    Vivier QuintiSerum™

    Regular price
    $276.00
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    $276.00
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    $276.00
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  • iS Clinical Super Serum Advanced+
    iS Clinical Super Serum Advanced+ iS Clinical Super Serum Advanced+

    iS Clinical Super Serum Advanced+

    Regular price
    $226.00
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    $226.00
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    $226.00
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  • GlyMed Accelerator Gel with 20% Alpha Hydroxy Acids
    GlyMed Accelerator Gel with 20% Alpha Hydroxy Acids GlyMed Accelerator Gel with 20% Alpha Hydroxy Acids

    GlyMed Accelerator Gel with 20% Alpha Hydroxy Acids

    Regular price
    $107.50
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    $107.50
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    AHAs (Glycolic Acid/Lactic Acid)
  • SkinCeuticals Discoloration Defense
    SkinCeuticals Discoloration Defense SkinCeuticals Discoloration Defense

    SkinCeuticals Discoloration Defense

    Regular price
    $172.00
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    $172.00
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    $172.00
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  • SkinCeuticals Silymarin CF
    SkinCeuticals Silymarin CF SkinCeuticals Silymarin CF

    SkinCeuticals Silymarin CF

    Regular price
    $230.00
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    $230.00
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    $230.00
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  • ZO Skin Health Brightalive Skin Brightener (30ml)
    ZO Skin Health Brightalive Skin Brightener (30ml)

    ZO Skin Health Brightalive Skin Brightener (30ml)

    Regular price
    $118.00
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    $118.00
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  • ZO Skin Health Peptide Facial Refining Concentrate
    ZO Skin Health Peptide Facial Refining Concentrate ZO Skin Health Peptide Facial Refining Concentrate

    ZO Skin Health Peptide Facial Refining Concentrate

    Regular price
    $355.00
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    $355.00
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  • Esthederm Derm Repair Restructuring Serum
    Esthederm Derm Repair Restructuring Serum Esthederm Derm Repair Restructuring Serum

    Esthederm Derm Repair Restructuring Serum

    Regular price
    $127.00
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    $127.00
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  • GMC Medical Antioxidant 20 Anti-Aging Serum
    GMC Medical Antioxidant 20 Anti-Aging Serum

    GMC Medical Antioxidant 20 Anti-Aging Serum

    Regular price
    $180.00
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    $180.00
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  • GM Collin Diamond Serum
    GM Collin Diamond Serum GM Collin Diamond Serum

    GM Collin Diamond Serum

    Regular price
    $300.00
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    $300.00
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  • GM Collin Vital C15 Serum
    GM Collin Vital C15 Serum GM Collin Vital C15 Serum

    GM Collin Vital C15 Serum

    Regular price
    $160.00
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    $160.00
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  • YonKa Serum C20
    YonKa Serum C20 YonKa Serum C20

    YonKa Serum C20

    Regular price
    $194.00
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    $194.00
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  • iS Clinical Youth Serum
    iS Clinical Youth Serum iS Clinical Youth Serum
    $16.00 Off

    iS Clinical Youth Serum

    Regular price
    $229.00
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    $229.00
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    $245.00
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  • Teoxane RHA Serum
    Teoxane RHA Serum Teoxane RHA Serum

    Teoxane RHA Serum

    Regular price
    $225.00
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    $225.00
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    $225.00
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  • Vivier GrenzCine® Serum
    Vivier GrenzCine® Serum Vivier GrenzCine® Serum

    Vivier GrenzCine® Serum

    Regular price
    $348.00
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    $348.00
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    $348.00
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    Advanced Regenerative Skincare
  • Alastin INhance Post-Injection Serum
    Alastin INhance Post-Injection Serum Alastin INhance Post-Injection Serum

    Alastin INhance Post-Injection Serum

    Regular price
    $87.00
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    $87.00
    Regular price
    Alastin
  • SkinCeuticals Retexturing Activator
    SkinCeuticals Retexturing Activator SkinCeuticals Retexturing Activator

    SkinCeuticals Retexturing Activator

    Regular price
    $125.00
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    $125.00
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    $125.00
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  • SkinCeuticals AGE Interrupter Ultra Serum
    SkinCeuticals AGE Interrupter Ultra Serum SkinCeuticals AGE Interrupter Ultra Serum

    SkinCeuticals AGE Interrupter Ultra Serum

    Regular price
    $215.00
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    $215.00
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    $215.00
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The Complete Guide to Serums & Oils

Serums are where visible change happens, delivering potent, targeted actives, antioxidants, retinol, peptides and brighteners, in concentrations creams cannot match. WeDoSkin carries medical-grade serums and oils from the professional brands clinics trust.

Browse best-selling serums below with live Canadian pricing, organised so you can find the right active for your concern.

🧪

High-Potency Actives

Concentrated vitamin C, retinol, peptides and growth factors.

🎯

Targeted Treatment

Choose a serum by concern: aging, pigment, redness or hydration.

🪶

Layer-Friendly

Lightweight textures absorb fast and layer under moisturiser.

🇨🇦

Authorized & Authentic

Fresh, correctly stored, sourced directly from the manufacturer.

The Science Behind Serums & Oils

How Serums & Oils's key actives work — and why formulation and delivery matter as much as the ingredient itself.

AM

Antioxidant Serums

Morning vitamin C and antioxidant serums defend against daytime free radicals.

PM

Retinol & Renewal

Evening retinol and resurfacing serums drive cell turnover while you sleep.

Hydrate

Hyaluronic & Soothing

Hydrating and calming serums layer with actives to support the barrier.

These descriptions reflect how each ingredient category works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.

Serums & Oils Bestsellers

The most-loved Serums & Oils products at WeDoSkin. Tap any product to shop.

Shop the Full Serums & Oils Range

Browse every Serums & Oils product by category, with live Canadian pricing.

How to Choose What's Right for You

New to Serums & Oils? Start with your primary concern — here's where most people begin.

Serums & Oils: Frequently Asked Questions

What does a face serum do?

A face serum delivers a high concentration of active ingredients, like vitamin C, retinol or hyaluronic acid, deep into the skin to target specific concerns more powerfully than a moisturizer.

In what order do I apply serums?

Apply serums after cleansing and before moisturizer, from thinnest to thickest texture. A common approach is an antioxidant serum in the morning and a retinol or treatment serum at night.

Can I use more than one serum?

Yes, but layer thoughtfully. Water-based serums go before oil-based ones, and some actives like vitamin C and retinol are often split between morning and night to reduce irritation.

What is the best anti-aging serum?

For aging, vitamin C serums like SkinCeuticals C E Ferulic protect by day and retinol serums renew by night. Peptide and growth-factor serums add firmness. The best choice depends on your skin's tolerance and goals.

Are facial oils good for oily skin?

Certain lightweight, non-comedogenic oils can balance oily skin, but those prone to congestion often prefer gel serums. Patch-test and introduce oils gradually.

How long until a serum shows results?

Hydrating serums work immediately, while treatment serums like retinol and vitamin C typically show visible results over 8 to 12 weeks of consistent use.

Medically reviewed by Dr. J. Porter
Medical Reviewer, WeDoSkin Clinic

Serum guidance here reflects standard dermatological principles on active ingredients and layering. As a Preferred Authorized Retailer, WeDoSkin stores and ships every formula correctly so actives stay potent. This is educational and not a substitute for personalized medical advice.

Last reviewed June 10, 2026 · WeDoSkin Clinic, Calgary · Educational information, not a substitute for personalized medical advice.

Explore Related Concerns & Ingredients

The concern and ingredient hubs Serums & Oils products most often appear in at WeDoSkin.

Why Canadians Choose WeDoSkin

Trusted by more than 100,000 customers, WeDoSkin.ca is a Preferred Authorized Retailer of medical-grade skincare in Canada — 45+ professional brands and 3,000+ products, with cashback rewards that never expire, 100-day returns, free Canada-wide shipping over $65, and free samples in every order.

Authorized & AuthenticEvery product is sourced directly from the brand — never grey-market — with full manufacturer warranty.
100,000+ Happy CustomersA trusted Canadian destination for medical-grade skincare, with thousands of verified reviews on Trustpilot, Google and Judge.me.
Rewards That Never ExpireEarn 5–20% cashback with no dated points and no minimum to redeem — more rewarding than typical points programs.
100-Day ReturnsReturn unopened products for a full 100 days, or opened products for 45 days through BuySure.
Free Shipping Over $65Fast, Canada-wide delivery, with complimentary samples included in every order.
45+ Brands, 3,000+ ProductsFrom ZO Skin Health and SkinCeuticals to Vivier, AlumierMD and dozens more — plus complimentary clinical guidance.

Why shop with WeDoSkin →

Questions about Serums & Oils?

Connect with a WeDoSkin clinical expert for a complimentary consultation.

Contact Our Skincare Experts