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Best Medical-Grade Serums in Canada

Serums are the treatment engine of a routine, delivering high concentrations of actives like vitamin C, retinol, peptides and hyaluronic acid deep into the skin. The best approach is to layer a targeted serum after cleansing and before moisturiser, choosing actives matched to your main concern. Shop medical-grade serums and facial oils from professional brands including SkinCeuticals, AlumierMD, Vivier, ZO Skin Health and iS Clinical — authentic and authorized in Canada.

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  • Obagi ELASTIderm® Facial Serum
    Obagi ELASTIderm® Facial Serum Obagi ELASTIderm® Facial Serum

    Obagi ELASTIderm® Facial Serum

    Regular price
    $320.00
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    $320.00
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  • Obagi ELASTIderm® Eye Serum
    Obagi ELASTIderm® Eye Serum Obagi ELASTIderm® Eye Serum

    Obagi ELASTIderm® Eye Serum

    Regular price
    $187.00
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    $187.00
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  • Obagi-C® Fx Clarifying Serum
    Obagi-C® Fx Clarifying Serum Obagi-C® Fx Clarifying Serum

    Obagi-C® Fx Clarifying Serum

    Regular price
    $283.59
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    $283.59
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    $207.00
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  • Esthederm Absolute Tightening Serum
    Esthederm Absolute Tightening Serum Esthederm Absolute Tightening Serum

    Esthederm Absolute Tightening Serum

    Regular price
    $149.00
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    $149.00
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  • Esthederm Intensive Vitamin E² Serum
    Esthederm Intensive Vitamin E² Serum Esthederm Intensive Vitamin E² Serum

    Esthederm Intensive Vitamin E² Serum

    Regular price
    $116.00
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    $116.00
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  • Esthederm Intensive Vitamine C2 Dual Concentrate
    Esthederm Intensive Vitamine C2 Dual Concentrate Esthederm Intensive Vitamine C2 Dual Concentrate

    Esthederm Intensive Vitamine C2 Dual Concentrate

    Regular price
    $59.00
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    $59.00
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  • Esthederm Intensive Spiruline Serum
    Esthederm Intensive Spiruline Serum Esthederm Intensive Spiruline Serum

    Esthederm Intensive Spiruline Serum

    Regular price
    $116.00
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    $116.00
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  • Esthederm Brightening Youth Serum
    Esthederm Brightening Youth Serum Esthederm Brightening Youth Serum

    Esthederm Brightening Youth Serum

    Regular price
    $126.00
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    $126.00
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  • BABOR ECM Repair Serum
    BABOR ECM Repair Serum BABOR ECM Repair Serum

    BABOR ECM Repair Serum

    Regular price
    $157.51
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    $157.51
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    $114.97
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  • COOLA Refreshing Water Plumping Gel Serum
    COOLA Refreshing Water Plumping Gel Serum COOLA Refreshing Water Plumping Gel Serum

    COOLA Refreshing Water Plumping Gel Serum

    Regular price
    $78.00
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    $78.00
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  • Colorescience All Calm Multi-Correction Serum
    Colorescience All Calm Multi-Correction Serum Colorescience All Calm Multi-Correction Serum

    Colorescience All Calm Multi-Correction Serum

    Regular price
    $129.90
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    $129.90
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    $129.90
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  • FOREO SUPERCHARGED Triple Action Firming Serum
    FOREO SUPERCHARGED Triple Action Firming Serum FOREO SUPERCHARGED Triple Action Firming Serum

    FOREO SUPERCHARGED Triple Action Firming Serum

    Regular price
    $99.00
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    $99.00
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  • FOREO SUPERCHARGED Overnight Skin Repair Face Oil
    FOREO SUPERCHARGED Overnight Skin Repair Face Oil FOREO SUPERCHARGED Overnight Skin Repair Face Oil

    FOREO SUPERCHARGED Overnight Skin Repair Face Oil

    Regular price
    $149.00
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    $149.00
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  • GM Collin Phyto Stem Cell+ Serum
    GM Collin Phyto Stem Cell+ Serum GM Collin Phyto Stem Cell+ Serum

    GM Collin Phyto Stem Cell+ Serum

    Regular price
    $160.00
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    $160.00
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  • YonKa Hydra N.1 Serum
    YonKa Hydra N.1 Serum YonKa Hydra N.1 Serum

    YonKa Hydra N.1 Serum

    Regular price
    $120.00
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    $120.00
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  • YonKa Nutri+ Booster
    YonKa Nutri+ Booster YonKa Nutri+ Booster

    YonKa Nutri+ Booster

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    $88.00
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    $88.00
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  • YonKa Hydra+ Booster
    YonKa Hydra+ Booster YonKa Hydra+ Booster

    YonKa Hydra+ Booster

    Regular price
    $88.00
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    $88.00
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  • YonKa Defense+ Booster
    YonKa Defense+ Booster YonKa Defense+ Booster

    YonKa Defense+ Booster

    Regular price
    $88.00
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    $88.00
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  • FOREO SUPERCHARGED Serum 2.0
    FOREO SUPERCHARGED Serum 2.0 FOREO SUPERCHARGED Serum 2.0

    FOREO SUPERCHARGED Serum 2.0

    Regular price
    $89.00
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    $89.00
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    $89.00
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  • iS Clinical Poly Vitamin Serum
    iS Clinical Poly Vitamin Serum iS Clinical Poly Vitamin Serum

    iS Clinical Poly Vitamin Serum

    Regular price
    $165.00
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    $165.00
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    $165.00
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    AHAs (Glycolic Acid/Lactic Acid)
  • iS Clinical Brightening Serum
    iS Clinical Brightening Serum iS Clinical Brightening Serum

    iS Clinical Brightening Serum

    Regular price
    $200.00
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    $200.00
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    $200.00
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  • iS Clinical GeneXC Serum
    iS Clinical GeneXC Serum iS Clinical GeneXC Serum

    iS Clinical GeneXC Serum

    Regular price
    $245.00
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    $245.00
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    $245.00
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  • iS Clinical Brightening Complex
    iS Clinical Brightening Complex iS Clinical Brightening Complex

    iS Clinical Brightening Complex

    Regular price
    $219.00
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    $219.00
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    $219.00
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The Complete Guide to Serums & Oils

Serums are where visible change happens, delivering potent, targeted actives, antioxidants, retinol, peptides and brighteners, in concentrations creams cannot match. WeDoSkin carries medical-grade serums and oils from the professional brands clinics trust.

Browse best-selling serums below with live Canadian pricing, organised so you can find the right active for your concern.

🧪

High-Potency Actives

Concentrated vitamin C, retinol, peptides and growth factors.

🎯

Targeted Treatment

Choose a serum by concern: aging, pigment, redness or hydration.

🪶

Layer-Friendly

Lightweight textures absorb fast and layer under moisturiser.

🇨🇦

Authorized & Authentic

Fresh, correctly stored, sourced directly from the manufacturer.

The Science Behind Serums & Oils

How Serums & Oils's key actives work — and why formulation and delivery matter as much as the ingredient itself.

AM

Antioxidant Serums

Morning vitamin C and antioxidant serums defend against daytime free radicals.

PM

Retinol & Renewal

Evening retinol and resurfacing serums drive cell turnover while you sleep.

Hydrate

Hyaluronic & Soothing

Hydrating and calming serums layer with actives to support the barrier.

These descriptions reflect how each ingredient category works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.

Serums & Oils Bestsellers

The most-loved Serums & Oils products at WeDoSkin. Tap any product to shop.

Shop the Full Serums & Oils Range

Browse every Serums & Oils product by category, with live Canadian pricing.

How to Choose What's Right for You

New to Serums & Oils? Start with your primary concern — here's where most people begin.

Serums & Oils: Frequently Asked Questions

What does a face serum do?

A face serum delivers a high concentration of active ingredients, like vitamin C, retinol or hyaluronic acid, deep into the skin to target specific concerns more powerfully than a moisturizer.

In what order do I apply serums?

Apply serums after cleansing and before moisturizer, from thinnest to thickest texture. A common approach is an antioxidant serum in the morning and a retinol or treatment serum at night.

Can I use more than one serum?

Yes, but layer thoughtfully. Water-based serums go before oil-based ones, and some actives like vitamin C and retinol are often split between morning and night to reduce irritation.

What is the best anti-aging serum?

For aging, vitamin C serums like SkinCeuticals C E Ferulic protect by day and retinol serums renew by night. Peptide and growth-factor serums add firmness. The best choice depends on your skin's tolerance and goals.

Are facial oils good for oily skin?

Certain lightweight, non-comedogenic oils can balance oily skin, but those prone to congestion often prefer gel serums. Patch-test and introduce oils gradually.

How long until a serum shows results?

Hydrating serums work immediately, while treatment serums like retinol and vitamin C typically show visible results over 8 to 12 weeks of consistent use.

Medically reviewed by Dr. J. Porter
Medical Reviewer, WeDoSkin Clinic

Serum guidance here reflects standard dermatological principles on active ingredients and layering. As a Preferred Authorized Retailer, WeDoSkin stores and ships every formula correctly so actives stay potent. This is educational and not a substitute for personalized medical advice.

Last reviewed June 10, 2026 · WeDoSkin Clinic, Calgary · Educational information, not a substitute for personalized medical advice.

Explore Related Concerns & Ingredients

The concern and ingredient hubs Serums & Oils products most often appear in at WeDoSkin.

Why Canadians Choose WeDoSkin

Trusted by more than 100,000 customers, WeDoSkin.ca is a Preferred Authorized Retailer of medical-grade skincare in Canada — 45+ professional brands and 3,000+ products, with cashback rewards that never expire, 100-day returns, free Canada-wide shipping over $65, and free samples in every order.

Authorized & AuthenticEvery product is sourced directly from the brand — never grey-market — with full manufacturer warranty.
100,000+ Happy CustomersA trusted Canadian destination for medical-grade skincare, with thousands of verified reviews on Trustpilot, Google and Judge.me.
Rewards That Never ExpireEarn 5–20% cashback with no dated points and no minimum to redeem — more rewarding than typical points programs.
100-Day ReturnsReturn unopened products for a full 100 days, or opened products for 45 days through BuySure.
Free Shipping Over $65Fast, Canada-wide delivery, with complimentary samples included in every order.
45+ Brands, 3,000+ ProductsFrom ZO Skin Health and SkinCeuticals to Vivier, AlumierMD and dozens more — plus complimentary clinical guidance.

Why shop with WeDoSkin →

Questions about Serums & Oils?

Connect with a WeDoSkin clinical expert for a complimentary consultation.

Contact Our Skincare Experts