Best Medical-Grade Serums in Canada
Serums are the treatment engine of a routine, delivering high concentrations of actives like vitamin C, retinol, peptides and hyaluronic acid deep into the skin. The best approach is to layer a targeted serum after cleansing and before moisturiser, choosing actives matched to your main concern. Shop medical-grade serums and facial oils from professional brands including SkinCeuticals, AlumierMD, Vivier, ZO Skin Health and iS Clinical — authentic and authorized in Canada.
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Neocutis Hyalis+ Serum
Neocutis Hyalis+ Serum
- Regular price
- $121.00
- Sale price
- $121.00
- Regular price
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Environ Focus Care Youth+® Tri-Peptide Complex+ Avance DFP312 Elixir
Environ Focus Care Youth+® Tri-Peptide Complex+ Avance DFP312 Elixir
- Regular price
- $150.00
- Sale price
- $150.00
- Regular price
- $150.00
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Obagi Professional-C® Serum 20%
Obagi Professional-C® Serum 20%
- Regular price
- $222.00
- Sale price
- $222.00
- Regular price
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Obagi Professional-C® Serum 15%
Obagi Professional-C® Serum 15%
- Regular price
- $186.00
- Sale price
- $186.00
- Regular price
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Obagi Professional-C® Serum 10%
Obagi Professional-C® Serum 10%
- Regular price
- $163.00
- Sale price
- $163.00
- Regular price
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Obagi ELASTIderm® Facial Serum
Obagi ELASTIderm® Facial Serum
- Regular price
- $320.00
- Sale price
- $320.00
- Regular price
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Obagi-C® Fx Clarifying Serum
Obagi-C® Fx Clarifying Serum
- Regular price
- $283.59
- Sale price
- $283.59
- Regular price
- $207.00
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Esthederm Absolute Tightening Serum
Esthederm Absolute Tightening Serum
- Regular price
- $149.00
- Sale price
- $149.00
- Regular price
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Esthederm Brightening Youth Serum
Esthederm Brightening Youth Serum
- Regular price
- $126.00
- Sale price
- $126.00
- Regular price
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BABOR ECM Repair Serum
BABOR ECM Repair Serum
- Regular price
- $157.51
- Sale price
- $157.51
- Regular price
- $114.97
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COOLA Refreshing Water Plumping Gel Serum
COOLA Refreshing Water Plumping Gel Serum
- Regular price
- $78.00
- Sale price
- $78.00
- Regular price
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GM Collin Dark Spot Serum
GM Collin Dark Spot Serum
- Regular price
- $110.00
- Sale price
- $110.00
- Regular price
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Colorescience Total Eye® Concentrate Serum Rollerball
Colorescience Total Eye® Concentrate Serum Rollerball
- Regular price
- $98.00
- Sale price
- $98.00
- Regular price
- $98.00
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Colorescience All Calm Multi-Correction Serum
Colorescience All Calm Multi-Correction Serum
- Regular price
- $129.90
- Sale price
- $129.90
- Regular price
- $129.90
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FOREO SUPERCHARGED Triple Action Firming Serum
FOREO SUPERCHARGED Triple Action Firming Serum
- Regular price
- $99.00
- Sale price
- $99.00
- Regular price
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FOREO SUPERCHARGED Overnight Skin Repair Face Oil
FOREO SUPERCHARGED Overnight Skin Repair Face Oil
- Regular price
- $149.00
- Sale price
- $149.00
- Regular price
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GM Collin Phyto Stem Cell+ Serum
GM Collin Phyto Stem Cell+ Serum
- Regular price
- $160.00
- Sale price
- $160.00
- Regular price
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GM Collin Diamond Serum
GM Collin Diamond Serum
- Regular price
- $300.00
- Sale price
- $300.00
- Regular price
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YonKa Hydra N.1 Serum
YonKa Hydra N.1 Serum
- Regular price
- $120.00
- Sale price
- $120.00
- Regular price
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YonKa Nutri+ Booster
YonKa Nutri+ Booster
- Regular price
- $88.00
- Sale price
- $88.00
- Regular price
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YonKa Hydra+ Booster
YonKa Hydra+ Booster
- Regular price
- $88.00
- Sale price
- $88.00
- Regular price
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YonKa Defense+ Booster
YonKa Defense+ Booster
- Regular price
- $88.00
- Sale price
- $88.00
- Regular price
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iS Clinical Poly Vitamin Serum
iS Clinical Poly Vitamin Serum
- Regular price
- $165.00
- Sale price
- $165.00
- Regular price
- $165.00
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The Complete Guide to Serums & Oils
Serums are where visible change happens, delivering potent, targeted actives, antioxidants, retinol, peptides and brighteners, in concentrations creams cannot match. WeDoSkin carries medical-grade serums and oils from the professional brands clinics trust.
Browse best-selling serums below with live Canadian pricing, organised so you can find the right active for your concern.
High-Potency Actives
Concentrated vitamin C, retinol, peptides and growth factors.
Targeted Treatment
Choose a serum by concern: aging, pigment, redness or hydration.
Layer-Friendly
Lightweight textures absorb fast and layer under moisturiser.
Authorized & Authentic
Fresh, correctly stored, sourced directly from the manufacturer.
The Science Behind Serums & Oils
How Serums & Oils's key actives work — and why formulation and delivery matter as much as the ingredient itself.
Antioxidant Serums
Morning vitamin C and antioxidant serums defend against daytime free radicals.
Retinol & Renewal
Evening retinol and resurfacing serums drive cell turnover while you sleep.
Hyaluronic & Soothing
Hydrating and calming serums layer with actives to support the barrier.
These descriptions reflect how each ingredient category works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.
Serums & Oils Bestsellers
The most-loved Serums & Oils products at WeDoSkin. Tap any product to shop.
Alumier Ultimate Boost Serum$141.00Shop now →
SkinCeuticals C E Ferulic — New 2026 Formula$230.00Shop now →
Alumier Retinol Resurfacing Serum 1.0%$153.00Shop now →
Vivier C E Peptides$222.00Shop now →
Alumier Intellibright Complex$136.00Shop now →
Alumier Alumience A.G.E.™$176.00Shop now →Shop the Full Serums & Oils Range
Browse every Serums & Oils product by category, with live Canadian pricing.
How to Choose What's Right for You
New to Serums & Oils? Start with your primary concern — here's where most people begin.
Serums & Oils: Frequently Asked Questions
What does a face serum do?
A face serum delivers a high concentration of active ingredients, like vitamin C, retinol or hyaluronic acid, deep into the skin to target specific concerns more powerfully than a moisturizer.
In what order do I apply serums?
Apply serums after cleansing and before moisturizer, from thinnest to thickest texture. A common approach is an antioxidant serum in the morning and a retinol or treatment serum at night.
Can I use more than one serum?
Yes, but layer thoughtfully. Water-based serums go before oil-based ones, and some actives like vitamin C and retinol are often split between morning and night to reduce irritation.
What is the best anti-aging serum?
For aging, vitamin C serums like SkinCeuticals C E Ferulic protect by day and retinol serums renew by night. Peptide and growth-factor serums add firmness. The best choice depends on your skin's tolerance and goals.
Are facial oils good for oily skin?
Certain lightweight, non-comedogenic oils can balance oily skin, but those prone to congestion often prefer gel serums. Patch-test and introduce oils gradually.
How long until a serum shows results?
Hydrating serums work immediately, while treatment serums like retinol and vitamin C typically show visible results over 8 to 12 weeks of consistent use.
Serum guidance here reflects standard dermatological principles on active ingredients and layering. As a Preferred Authorized Retailer, WeDoSkin stores and ships every formula correctly so actives stay potent. This is educational and not a substitute for personalized medical advice.
Explore Related Concerns & Ingredients
The concern and ingredient hubs Serums & Oils products most often appear in at WeDoSkin.
Why Canadians Choose WeDoSkin
Trusted by more than 100,000 customers, WeDoSkin.ca is a Preferred Authorized Retailer of medical-grade skincare in Canada — 45+ professional brands and 3,000+ products, with cashback rewards that never expire, 100-day returns, free Canada-wide shipping over $65, and free samples in every order.
Questions about Serums & Oils?
Connect with a WeDoSkin clinical expert for a complimentary consultation.
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