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Best Medical-Grade Serums in Canada

Serums are the treatment engine of a routine, delivering high concentrations of actives like vitamin C, retinol, peptides and hyaluronic acid deep into the skin. The best approach is to layer a targeted serum after cleansing and before moisturiser, choosing actives matched to your main concern. Shop medical-grade serums and facial oils from professional brands including SkinCeuticals, AlumierMD, Vivier, ZO Skin Health and iS Clinical — authentic and authorized in Canada.

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  • SkinCeuticals Retexturing Activator
    SkinCeuticals Retexturing Activator SkinCeuticals Retexturing Activator

    SkinCeuticals Retexturing Activator

    Regular price
    $125.00
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    $125.00
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  • SkinCeuticals AGE Interrupter Ultra Serum
    SkinCeuticals AGE Interrupter Ultra Serum SkinCeuticals AGE Interrupter Ultra Serum

    SkinCeuticals AGE Interrupter Ultra Serum

    Regular price
    $215.00
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    $215.00
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  • Esthederm Intensive Pro-Collagen+ Serum
    Esthederm Intensive Pro-Collagen+ Serum Esthederm Intensive Pro-Collagen+ Serum

    Esthederm Intensive Pro-Collagen+ Serum

    Regular price
    $119.00
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    $119.00
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  • Esthederm E.V.E. Serum Source
    Esthederm E.V.E. Serum Source Esthederm E.V.E. Serum Source

    Esthederm E.V.E. Serum Source

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    $145.00
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    $145.00
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  • Esthederm Age Proteom™ Advanced Serum
    Esthederm Age Proteom™ Advanced Serum Esthederm Age Proteom™ Advanced Serum

    Esthederm Age Proteom™ Advanced Serum

    Regular price
    $139.00
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    $139.00
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  • BABOR Best of Biogen Regeneration Routine Set (Limited Edition)
    BABOR Best of Biogen Regeneration Routine Set (Limited Edition)

    BABOR Best of Biogen Regeneration Routine Set (Limited Edition)

    Regular price
    $185.00
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    $185.00
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    $185.00
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  • GM Collin Dark Spot Serum
    GM Collin Dark Spot Serum GM Collin Dark Spot Serum

    GM Collin Dark Spot Serum

    Regular price
    $110.00
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    $110.00
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  • GM Collin Hydramucine Optimal Serum
    GM Collin Hydramucine Optimal Serum GM Collin Hydramucine Optimal Serum

    GM Collin Hydramucine Optimal Serum

    Regular price
    $90.00
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    $90.00
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  • GM Collin City D-Tox Serum
    GM Collin City D-Tox Serum GM Collin City D-Tox Serum

    GM Collin City D-Tox Serum

    Regular price
    $85.00
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    $85.00
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  • GM Collin Hyaluronic Filler Serum
    GM Collin Hyaluronic Filler Serum GM Collin Hyaluronic Filler Serum

    GM Collin Hyaluronic Filler Serum

    Regular price
    $130.00
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    $130.00
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  • GM Collin 4D Visible Lifting Neck & Décolleté Serum
    GM Collin 4D Visible Lifting Neck & Décolleté Serum GM Collin 4D Visible Lifting Neck & Décolleté Serum

    GM Collin 4D Visible Lifting Neck & Décolleté Serum

    Regular price
    $160.00
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    $160.00
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  • iS Clinical NeckPerfect Complex
    iS Clinical NeckPerfect Complex iS Clinical NeckPerfect Complex

    iS Clinical NeckPerfect Complex

    Regular price
    $158.00
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    $158.00
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    $158.00
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  • Alastin INhance Post-Injection Serum
    Alastin INhance Post-Injection Serum Alastin INhance Post-Injection Serum

    Alastin INhance Post-Injection Serum

    Regular price
    $87.00
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    $87.00
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    Alastin
  • Payot Renewing Peeling Serum
    Payot Renewing Peeling Serum Payot Renewing Peeling Serum

    Payot Renewing Peeling Serum

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    $74.50
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    $74.50
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  • Forlle'd Hyalogy AC Clear Essence
    Forlle'd Hyalogy AC Clear Essence Forlle'd Hyalogy AC Clear Essence

    Forlle'd Hyalogy AC Clear Essence

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    $150.00
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    $150.00
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  • Forlle'd Hyalogy P-effect Essence
    Forlle'd Hyalogy P-effect Essence Forlle'd Hyalogy P-effect Essence

    Forlle'd Hyalogy P-effect Essence

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    $420.00
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    $420.00
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  • SkinBetter Mystro Active Balance Serum
    SkinBetter Mystro Active Balance Serum SkinBetter Mystro Active Balance Serum

    SkinBetter Mystro Active Balance Serum

    Regular price
    $320.00
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    $320.00
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    $320.00
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  • Neocutis Hyalis+ Serum
    Neocutis Hyalis+ Serum Neocutis Hyalis+ Serum

    Neocutis Hyalis+ Serum

    Regular price
    $121.00
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    $121.00
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  • Environ Focus Care Youth+® Tri-Peptide Complex+ Avance DFP312 Elixir
    Environ Focus Care Youth+® Tri-Peptide Complex+ Avance DFP312 Elixir Environ Focus Care Youth+® Tri-Peptide Complex+ Avance DFP312 Elixir

    Environ Focus Care Youth+® Tri-Peptide Complex+ Avance DFP312 Elixir

    Regular price
    $150.00
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    $150.00
    Regular price
    $150.00
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  • Obagi Daily Hydro Drops Facial Serum
    Obagi Daily Hydro Drops Facial Serum Obagi Daily Hydro Drops Facial Serum

    Obagi Daily Hydro Drops Facial Serum

    Regular price
    $163.00
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    $163.00
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  • Obagi Professional-C® Serum 15%
    Obagi Professional-C® Serum 15% Obagi Professional-C® Serum 15%

    Obagi Professional-C® Serum 15%

    Regular price
    $186.00
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    $186.00
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  • Obagi Professional-C® Serum 10%
    Obagi Professional-C® Serum 10% Obagi Professional-C® Serum 10%

    Obagi Professional-C® Serum 10%

    Regular price
    $163.00
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    $163.00
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  • Obagi ELASTIderm® Facial Serum
    Obagi ELASTIderm® Facial Serum Obagi ELASTIderm® Facial Serum

    Obagi ELASTIderm® Facial Serum

    Regular price
    $320.00
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    $320.00
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The Complete Guide to Serums & Oils

Serums are where visible change happens, delivering potent, targeted actives, antioxidants, retinol, peptides and brighteners, in concentrations creams cannot match. WeDoSkin carries medical-grade serums and oils from the professional brands clinics trust.

Browse best-selling serums below with live Canadian pricing, organised so you can find the right active for your concern.

🧪

High-Potency Actives

Concentrated vitamin C, retinol, peptides and growth factors.

🎯

Targeted Treatment

Choose a serum by concern: aging, pigment, redness or hydration.

🪶

Layer-Friendly

Lightweight textures absorb fast and layer under moisturiser.

🇨🇦

Authorized & Authentic

Fresh, correctly stored, sourced directly from the manufacturer.

The Science Behind Serums & Oils

How Serums & Oils's key actives work — and why formulation and delivery matter as much as the ingredient itself.

AM

Antioxidant Serums

Morning vitamin C and antioxidant serums defend against daytime free radicals.

PM

Retinol & Renewal

Evening retinol and resurfacing serums drive cell turnover while you sleep.

Hydrate

Hyaluronic & Soothing

Hydrating and calming serums layer with actives to support the barrier.

These descriptions reflect how each ingredient category works in general dermatological terms. Individual results vary, and skincare is not a substitute for professional medical advice.

Serums & Oils Bestsellers

The most-loved Serums & Oils products at WeDoSkin. Tap any product to shop.

Shop the Full Serums & Oils Range

Browse every Serums & Oils product by category, with live Canadian pricing.

How to Choose What's Right for You

New to Serums & Oils? Start with your primary concern — here's where most people begin.

Serums & Oils: Frequently Asked Questions

What does a face serum do?

A face serum delivers a high concentration of active ingredients, like vitamin C, retinol or hyaluronic acid, deep into the skin to target specific concerns more powerfully than a moisturizer.

In what order do I apply serums?

Apply serums after cleansing and before moisturizer, from thinnest to thickest texture. A common approach is an antioxidant serum in the morning and a retinol or treatment serum at night.

Can I use more than one serum?

Yes, but layer thoughtfully. Water-based serums go before oil-based ones, and some actives like vitamin C and retinol are often split between morning and night to reduce irritation.

What is the best anti-aging serum?

For aging, vitamin C serums like SkinCeuticals C E Ferulic protect by day and retinol serums renew by night. Peptide and growth-factor serums add firmness. The best choice depends on your skin's tolerance and goals.

Are facial oils good for oily skin?

Certain lightweight, non-comedogenic oils can balance oily skin, but those prone to congestion often prefer gel serums. Patch-test and introduce oils gradually.

How long until a serum shows results?

Hydrating serums work immediately, while treatment serums like retinol and vitamin C typically show visible results over 8 to 12 weeks of consistent use.

Medically reviewed by Dr. J. Porter
Medical Reviewer, WeDoSkin Clinic

Serum guidance here reflects standard dermatological principles on active ingredients and layering. As a Preferred Authorized Retailer, WeDoSkin stores and ships every formula correctly so actives stay potent. This is educational and not a substitute for personalized medical advice.

Last reviewed June 10, 2026 · WeDoSkin Clinic, Calgary · Educational information, not a substitute for personalized medical advice.

Explore Related Concerns & Ingredients

The concern and ingredient hubs Serums & Oils products most often appear in at WeDoSkin.

Why Canadians Choose WeDoSkin

Trusted by more than 100,000 customers, WeDoSkin.ca is a Preferred Authorized Retailer of medical-grade skincare in Canada — 45+ professional brands and 3,000+ products, with cashback rewards that never expire, 100-day returns, free Canada-wide shipping over $65, and free samples in every order.

Authorized & AuthenticEvery product is sourced directly from the brand — never grey-market — with full manufacturer warranty.
100,000+ Happy CustomersA trusted Canadian destination for medical-grade skincare, with thousands of verified reviews on Trustpilot, Google and Judge.me.
Rewards That Never ExpireEarn 5–20% cashback with no dated points and no minimum to redeem — more rewarding than typical points programs.
100-Day ReturnsReturn unopened products for a full 100 days, or opened products for 45 days through BuySure.
Free Shipping Over $65Fast, Canada-wide delivery, with complimentary samples included in every order.
45+ Brands, 3,000+ ProductsFrom ZO Skin Health and SkinCeuticals to Vivier, AlumierMD and dozens more — plus complimentary clinical guidance.

Why shop with WeDoSkin →

Questions about Serums & Oils?

Connect with a WeDoSkin clinical expert for a complimentary consultation.

Contact Our Skincare Experts